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A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells
BACKGROUND: Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evolution and tumor progression, recent findings point to the existence of a thresh...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671967/ https://www.ncbi.nlm.nih.gov/pubmed/23694679 http://dx.doi.org/10.1186/1471-2407-13-252 |