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Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study

BACKGROUND: Previous studies have demonstrated functional and structural temporal lobe abnormalities located close to the auditory cortical regions in schizophrenia. The goal of this study was to determine whether functional abnormalities exist in the cortical processing of musical sound in schizoph...

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Autores principales: Wu, Kuan-Yi, Chao, Ching-Wen, Hung, Ching-I, Chen, Wei-Hong, Chen, Yung-Ting, Liang, Sheng-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671979/
https://www.ncbi.nlm.nih.gov/pubmed/23721126
http://dx.doi.org/10.1186/1471-244X-13-158
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author Wu, Kuan-Yi
Chao, Ching-Wen
Hung, Ching-I
Chen, Wei-Hong
Chen, Yung-Ting
Liang, Sheng-Fu
author_facet Wu, Kuan-Yi
Chao, Ching-Wen
Hung, Ching-I
Chen, Wei-Hong
Chen, Yung-Ting
Liang, Sheng-Fu
author_sort Wu, Kuan-Yi
collection PubMed
description BACKGROUND: Previous studies have demonstrated functional and structural temporal lobe abnormalities located close to the auditory cortical regions in schizophrenia. The goal of this study was to determine whether functional abnormalities exist in the cortical processing of musical sound in schizophrenia. METHODS: Twelve schizophrenic patients and twelve age- and sex-matched healthy controls were recruited, and participants listened to a random sequence of two kinds of sonic entities, intervals (tritones and perfect fifths) and chords (atonal chords, diminished chords, and major triads), of varying degrees of complexity and consonance. The perception of musical sound was investigated by the auditory evoked potentials technique. RESULTS: Our results showed that schizophrenic patients exhibited significant reductions in the amplitudes of the N1 and P2 components elicited by musical stimuli, to which consonant sounds contributed more significantly than dissonant sounds. Schizophrenic patients could not perceive the dissimilarity between interval and chord stimuli based on the evoked potentials responses as compared with the healthy controls. CONCLUSION: This study provided electrophysiological evidence of functional abnormalities in the cortical processing of sound complexity and music consonance in schizophrenia. The preliminary findings warrant further investigations for the underlying mechanisms.
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spelling pubmed-36719792013-06-05 Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study Wu, Kuan-Yi Chao, Ching-Wen Hung, Ching-I Chen, Wei-Hong Chen, Yung-Ting Liang, Sheng-Fu BMC Psychiatry Research Article BACKGROUND: Previous studies have demonstrated functional and structural temporal lobe abnormalities located close to the auditory cortical regions in schizophrenia. The goal of this study was to determine whether functional abnormalities exist in the cortical processing of musical sound in schizophrenia. METHODS: Twelve schizophrenic patients and twelve age- and sex-matched healthy controls were recruited, and participants listened to a random sequence of two kinds of sonic entities, intervals (tritones and perfect fifths) and chords (atonal chords, diminished chords, and major triads), of varying degrees of complexity and consonance. The perception of musical sound was investigated by the auditory evoked potentials technique. RESULTS: Our results showed that schizophrenic patients exhibited significant reductions in the amplitudes of the N1 and P2 components elicited by musical stimuli, to which consonant sounds contributed more significantly than dissonant sounds. Schizophrenic patients could not perceive the dissimilarity between interval and chord stimuli based on the evoked potentials responses as compared with the healthy controls. CONCLUSION: This study provided electrophysiological evidence of functional abnormalities in the cortical processing of sound complexity and music consonance in schizophrenia. The preliminary findings warrant further investigations for the underlying mechanisms. BioMed Central 2013-05-30 /pmc/articles/PMC3671979/ /pubmed/23721126 http://dx.doi.org/10.1186/1471-244X-13-158 Text en Copyright © 2013 Wu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Kuan-Yi
Chao, Ching-Wen
Hung, Ching-I
Chen, Wei-Hong
Chen, Yung-Ting
Liang, Sheng-Fu
Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
title Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
title_full Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
title_fullStr Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
title_full_unstemmed Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
title_short Functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
title_sort functional abnormalities in the cortical processing of sound complexity and musical consonance in schizophrenia: evidence from an evoked potential study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671979/
https://www.ncbi.nlm.nih.gov/pubmed/23721126
http://dx.doi.org/10.1186/1471-244X-13-158
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