Vascular endothelial growth factor-B expression in postischemic rat brain

BACKGROUND: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain. METHODS: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1–7 days after middle cerebral artery occlusion in ra...

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Detalles Bibliográficos
Autores principales: Xie, Lin, Mao, Xiaoou, Jin, Kunlin, Greenberg, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671984/
https://www.ncbi.nlm.nih.gov/pubmed/23601533
http://dx.doi.org/10.1186/2045-824X-5-8
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author Xie, Lin
Mao, Xiaoou
Jin, Kunlin
Greenberg, David A
author_facet Xie, Lin
Mao, Xiaoou
Jin, Kunlin
Greenberg, David A
author_sort Xie, Lin
collection PubMed
description BACKGROUND: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain. METHODS: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1–7 days after middle cerebral artery occlusion in rats. RESULTS: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells. CONCLUSIONS: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.
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spelling pubmed-36719842013-06-05 Vascular endothelial growth factor-B expression in postischemic rat brain Xie, Lin Mao, Xiaoou Jin, Kunlin Greenberg, David A Vasc Cell Research BACKGROUND: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain. METHODS: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1–7 days after middle cerebral artery occlusion in rats. RESULTS: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells. CONCLUSIONS: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia. BioMed Central 2013-04-20 /pmc/articles/PMC3671984/ /pubmed/23601533 http://dx.doi.org/10.1186/2045-824X-5-8 Text en Copyright © 2013 Xie et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Xie, Lin
Mao, Xiaoou
Jin, Kunlin
Greenberg, David A
Vascular endothelial growth factor-B expression in postischemic rat brain
title Vascular endothelial growth factor-B expression in postischemic rat brain
title_full Vascular endothelial growth factor-B expression in postischemic rat brain
title_fullStr Vascular endothelial growth factor-B expression in postischemic rat brain
title_full_unstemmed Vascular endothelial growth factor-B expression in postischemic rat brain
title_short Vascular endothelial growth factor-B expression in postischemic rat brain
title_sort vascular endothelial growth factor-b expression in postischemic rat brain
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671984/
https://www.ncbi.nlm.nih.gov/pubmed/23601533
http://dx.doi.org/10.1186/2045-824X-5-8
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AT maoxiaoou vascularendothelialgrowthfactorbexpressioninpostischemicratbrain
AT jinkunlin vascularendothelialgrowthfactorbexpressioninpostischemicratbrain
AT greenbergdavida vascularendothelialgrowthfactorbexpressioninpostischemicratbrain

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