Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature

BACKGROUND: Primary adenocarcinoma of thymus is extremely rare. CASE PRESENTATION: This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistoche...

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Autores principales: Maghbool, Maryam, Ramzi, Mani, Nagel, Inga, Bejarano, Pablo, Siebert, Reiner, Saeedzadeh, Abolfazl, Daneshbod, Yahya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672093/
https://www.ncbi.nlm.nih.gov/pubmed/23725376
http://dx.doi.org/10.1186/1472-6890-13-17
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author Maghbool, Maryam
Ramzi, Mani
Nagel, Inga
Bejarano, Pablo
Siebert, Reiner
Saeedzadeh, Abolfazl
Daneshbod, Yahya
author_facet Maghbool, Maryam
Ramzi, Mani
Nagel, Inga
Bejarano, Pablo
Siebert, Reiner
Saeedzadeh, Abolfazl
Daneshbod, Yahya
author_sort Maghbool, Maryam
collection PubMed
description BACKGROUND: Primary adenocarcinoma of thymus is extremely rare. CASE PRESENTATION: This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32. CONCLUSION: This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.
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spelling pubmed-36720932013-06-05 Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature Maghbool, Maryam Ramzi, Mani Nagel, Inga Bejarano, Pablo Siebert, Reiner Saeedzadeh, Abolfazl Daneshbod, Yahya BMC Clin Pathol Case Report BACKGROUND: Primary adenocarcinoma of thymus is extremely rare. CASE PRESENTATION: This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32. CONCLUSION: This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors. BioMed Central 2013-05-31 /pmc/articles/PMC3672093/ /pubmed/23725376 http://dx.doi.org/10.1186/1472-6890-13-17 Text en Copyright © 2013 Maghbool et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maghbool, Maryam
Ramzi, Mani
Nagel, Inga
Bejarano, Pablo
Siebert, Reiner
Saeedzadeh, Abolfazl
Daneshbod, Yahya
Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
title Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
title_full Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
title_fullStr Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
title_full_unstemmed Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
title_short Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
title_sort primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672093/
https://www.ncbi.nlm.nih.gov/pubmed/23725376
http://dx.doi.org/10.1186/1472-6890-13-17
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