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CXCR3 blockade: a novel anti-sepsis approach?
Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672571/ https://www.ncbi.nlm.nih.gov/pubmed/23171733 http://dx.doi.org/10.1186/cc11818 |
| _version_ | 1782272127943049216 |
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| author | Delano, Matthew J Moldawer, Lyle L |
| author_facet | Delano, Matthew J Moldawer, Lyle L |
| author_sort | Delano, Matthew J |
| collection | PubMed |
| description | Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed. |
| format | Online Article Text |
| id | pubmed-3672571 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36725712013-11-21 CXCR3 blockade: a novel anti-sepsis approach? Delano, Matthew J Moldawer, Lyle L Crit Care Commentary Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed. BioMed Central 2012 2012-11-21 /pmc/articles/PMC3672571/ /pubmed/23171733 http://dx.doi.org/10.1186/cc11818 Text en Copyright ©2012 BioMed Central Ltd |
| spellingShingle | Commentary Delano, Matthew J Moldawer, Lyle L CXCR3 blockade: a novel anti-sepsis approach? |
| title | CXCR3 blockade: a novel anti-sepsis approach? |
| title_full | CXCR3 blockade: a novel anti-sepsis approach? |
| title_fullStr | CXCR3 blockade: a novel anti-sepsis approach? |
| title_full_unstemmed | CXCR3 blockade: a novel anti-sepsis approach? |
| title_short | CXCR3 blockade: a novel anti-sepsis approach? |
| title_sort | cxcr3 blockade: a novel anti-sepsis approach? |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672571/ https://www.ncbi.nlm.nih.gov/pubmed/23171733 http://dx.doi.org/10.1186/cc11818 |
| work_keys_str_mv | AT delanomatthewj cxcr3blockadeanovelantisepsisapproach AT moldawerlylel cxcr3blockadeanovelantisepsisapproach |