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Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

INTRODUCTION: Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) in the nucleus pulposus (NP) to chondrocyte-like cells (CLCs). The purpose of this study was to investigate the gene expression profiles involved in this proce...

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Detalles Bibliográficos
Autores principales:	Smolders, Lucas A, Meij, Björn P, Onis, David, Riemers, Frank M, Bergknut, Niklas, Wubbolts, Richard, Grinwis, Guy CM, Houweling, Martin, Groot Koerkamp, Marian JA, van Leenen, Dik, Holstege, Frank CP, Hazewinkel, Herman AW, Creemers, Laura B, Penning, Louis C, Tryfonidou, Marianna A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672710/ https://www.ncbi.nlm.nih.gov/pubmed/23360510 http://dx.doi.org/10.1186/ar4157

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