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Perspectives on epigenetic-based immune intervention for rheumatic diseases
Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lup...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672716/ https://www.ncbi.nlm.nih.gov/pubmed/23510070 http://dx.doi.org/10.1186/ar4167 |
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author | Gray, Steven G |
author_facet | Gray, Steven G |
author_sort | Gray, Steven G |
collection | PubMed |
description | Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus and rheumatoid arthritis. A significant body of evidence now links aberrant epigenetic regulation of gene expression with rheumatic disease and points toward the use of epigenetic targeting agents as potential new treatment options, particularly for those conditions associated with an autoimmune element. In this perspective, I will briefly cover the current knowledge surrounding this area in the field of rheumatology. |
format | Online Article Text |
id | pubmed-3672716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36727162013-09-14 Perspectives on epigenetic-based immune intervention for rheumatic diseases Gray, Steven G Arthritis Res Ther Review Rheumatic disease can loosely be described as any painful condition affecting the loco-motor system, including joints, muscles, connective tissues, and soft tissues around the joints and bones. There is a wide spectrum of rheumatic diseases, many of which involve autoimmunity, including systemic lupus erythematosus and rheumatoid arthritis. A significant body of evidence now links aberrant epigenetic regulation of gene expression with rheumatic disease and points toward the use of epigenetic targeting agents as potential new treatment options, particularly for those conditions associated with an autoimmune element. In this perspective, I will briefly cover the current knowledge surrounding this area in the field of rheumatology. BioMed Central 2013 2013-03-14 /pmc/articles/PMC3672716/ /pubmed/23510070 http://dx.doi.org/10.1186/ar4167 Text en Copyright © 2013 BioMed Central Ltd |
spellingShingle | Review Gray, Steven G Perspectives on epigenetic-based immune intervention for rheumatic diseases |
title | Perspectives on epigenetic-based immune intervention for rheumatic diseases |
title_full | Perspectives on epigenetic-based immune intervention for rheumatic diseases |
title_fullStr | Perspectives on epigenetic-based immune intervention for rheumatic diseases |
title_full_unstemmed | Perspectives on epigenetic-based immune intervention for rheumatic diseases |
title_short | Perspectives on epigenetic-based immune intervention for rheumatic diseases |
title_sort | perspectives on epigenetic-based immune intervention for rheumatic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672716/ https://www.ncbi.nlm.nih.gov/pubmed/23510070 http://dx.doi.org/10.1186/ar4167 |
work_keys_str_mv | AT graysteveng perspectivesonepigeneticbasedimmuneinterventionforrheumaticdiseases |