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A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer

INTRODUCTION: Cyclooxygenase-2 (COX-2) is frequently over-expressed in primary breast cancer. In transgenic breast cancer models, over-expression of COX-2 leads to tumour formation while COX-2 inhibition exerts anti-tumour effects in breast cancer cell lines. To further determine the effect of COX-2...

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Detalles Bibliográficos
Autores principales:	Brandão, Rita D, Veeck, Jürgen, Van de Vijver, Koen K, Lindsey, Patrick, de Vries, Bart, van Elssen, Catharina HMJ, Blok, Marinus J, Keymeulen, Kristien, Ayoubi, Torik, Smeets, Hubert JM, Tjan-Heijnen, Vivianne C, Hupperets, Pierre S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672758/ https://www.ncbi.nlm.nih.gov/pubmed/23566419 http://dx.doi.org/10.1186/bcr3409

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