Cargando…

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer

INTRODUCTION: Elafin is an elastase-specific inhibitor with increased transcription in normal mammary epithelial cells compared to mammary carcinoma cells. In this report, we test the hypothesis that inhibition of elastase, through induction of elafin, leads to inhibition of human breast cancer cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hunt, Kelly K, Wingate, Hannah, Yokota, Tomoya, Liu, Yanna, Mills, Gordon B, Zhang, Fan, Fang, Bingliang, Su, Chun-Hui, Zhang, Ming, Yi, Min, Keyomarsi, Khandan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672770/ https://www.ncbi.nlm.nih.gov/pubmed/23320734 http://dx.doi.org/10.1186/bcr3374

Ejemplares similares

The Serine Protease Inhibitor Elafin Maintains Normal Growth Control by Opposing the Mitogenic Effects of Neutrophil Elastase
por: Caruso, Joseph A., et al.
Publicado: (2014)

Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
por: Caruso, Joseph A, et al.
Publicado: (2014)

Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence
por: Caruso, Joseph A, et al.
Publicado: (2015)

Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with Acute Respiratory Distress Syndrome (ARDS) Development
por: Wang, Zhaoxi, et al.
Publicado: (2009)

Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency
por: Sweatt, Andrew J., et al.
Publicado: (2021)

LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients
por: Duong, MyLinh T., et al.
Publicado: (2012)

The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease
por: Sallenave, Jean-Michel
Publicado: (2000)

Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β(1) are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
por: Thomassen, Jan C., et al.
Publicado: (2021)

PKC iota promotes ovarian tumor progression through deregulation of cyclin E
por: Nanos-Webb, Angela, et al.
Publicado: (2015)

Low-molecular-weight cyclin E: the missing link between biology and clinical outcome
por: Akli, Said, et al.
Publicado: (2004)

Elafin: a double agent in breast and ovarian cancer
por: Feng, Yi, et al.
Publicado: (2015)

High Expression and Clinical Significance of Elafin in Colorectal Cancer
por: Liu, Yun, et al.
Publicado: (2019)

Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris
por: Holmannova, Drahomira, et al.
Publicado: (2020)

Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells against cytotoxic chemotherapy in breast cancer
por: Mull, Benjamin B., et al.
Publicado: (2020)

Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2
por: Yin, Lei, et al.
Publicado: (2010)

Leveraging MYC as a therapeutic treatment option for TNBC
por: Carey, Jason P.W., et al.
Publicado: (2018)

Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus.
por: Yamamoto, S., et al.
Publicado: (1997)

Clinical Significance of Serum Elafin in Children with Inflammatory Bowel Disease
por: Krawiec, Paulina, et al.
Publicado: (2022)

Elastase inhibitor. Characterization of the human elastase inhibitor molecule associated with monocytes, macrophages, and neutrophils
Publicado: (1989)

A Novel Interaction Between HER2/neu and Cyclin E in Breast Cancer
por: Mittendorf, Elizabeth A., et al.
Publicado: (2010)

Elafin drives poor outcome in high grade serous ovarian cancers and basal-like breast tumors
por: Labidi-Galy, S. Intidhar, et al.
Publicado: (2014)

Serum Elafin as a Potential Marker of Disease Activity in Behçet's Disease
por: Kutlay, Armagan, et al.
Publicado: (2023)

Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles
por: Moghadam, Sonia Javan, et al.
Publicado: (2011)

High Serum Elafin Prediction of Poor Prognosis of Locoregional Esophageal Squamous Cell Carcinoma
por: Wu, I-Chen, et al.
Publicado: (2021)

The Natural Polypeptides as Significant Elastase Inhibitors
por: Ahmad, Shabir, et al.
Publicado: (2020)

Flavonoids as inhibitors of human neutrophil elastase
por: Jakimiuk, Katarzyna, et al.
Publicado: (2021)

Elafin as a Prognostic Marker in Esophageal Squamous Cell Carcinoma: A Pilot Study Using Three-Dimensional Imaging and Genomic Profiling
por: Chen, Wei-Chung, et al.
Publicado: (2023)

High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures
por: Wang, Jiani, et al.
Publicado: (2020)

Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer
por: Lu, Weiyu, et al.
Publicado: (2023)

Elafin and its precursor trappin‐2: What is their therapeutic potential for intestinal diseases?
por: Deraison, Céline, et al.
Publicado: (2022)

Secretory Leukocyte Protease Inhibitor (SLPI) Is, like Its Homologue Trappin-2 (Pre-Elafin), a Transglutaminase Substrate
por: Baranger, Kévin, et al.
Publicado: (2011)

Neutrophil Elastase Inhibitors and Chronic Kidney Disease
por: Bronze-da-Rocha, Elsa, et al.
Publicado: (2018)

Diazaborines as New Inhibitors of Human Neutrophil Elastase
por: António, João P. M., et al.
Publicado: (2018)

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells
por: Jasinghe, Viraj J., et al.
Publicado: (2013)

Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2
por: Xie, Ying, et al.
Publicado: (2022)

LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers
por: Lulla, Amriti R., et al.
Publicado: (2021)

Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery: a randomised-controlled trial
por: Alam, S R, et al.
Publicado: (2015)

Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice
por: Wang, Jiani, et al.
Publicado: (2020)

Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma
por: Wang, Chenwei, et al.
Publicado: (2021)

A fast-acting elastase inhibitor in human monocytes
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_7nlcpj5cj5tgp13c8cip11qcql