Germline deletion of β2 microglobulin or CD1d reduces anti-phospholipid antibody, but increases autoantibodies against non-phospholipid antigens in the NZB/W F1 model of lupus

INTRODUCTION: β2-microglobulin (β2m) is required for the surface expression of MHC class I and class I-like proteins such as CD1d, Qa1 and neonatal Fc receptor (FcRn), all of which may impact the development of autoimmunity. Since CD1d is known to bind and present phospholipid antigens to T cells, w...

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Detalles Bibliográficos
Autores principales: Singh, Ram Raj, Yang, Jun-Qi, Kim, Peter J, Halder, Ramesh C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672782/
https://www.ncbi.nlm.nih.gov/pubmed/23531237
http://dx.doi.org/10.1186/ar4206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672782/
https://www.ncbi.nlm.nih.gov/pubmed/23531237
http://dx.doi.org/10.1186/ar4206

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