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It takes two to tango in the microenvironment!
Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E(2 )produced by epithelial cells...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672805/ https://www.ncbi.nlm.nih.gov/pubmed/23510134 http://dx.doi.org/10.1186/bcr3388 |
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author | Ursini-Siegel, Josie Park, Morag |
author_facet | Ursini-Siegel, Josie Park, Morag |
author_sort | Ursini-Siegel, Josie |
collection | PubMed |
description | Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E(2 )produced by epithelial cells and, in turn, promoted enhanced migration of epithelial cells. These events in epithelial cells in vitro, including telomere loss, heightened DNA damage response, and activin A expression, are observed in breast ductal carcinoma in situ lesions surrounded by stroma bearing hallmarks of activated fibroblasts and immune and endothelial cell infiltration. Thus, reciprocal epithelial-stromal interactions facilitate progression to malignancy and occur even at the earliest stages of mammary tumorigenesis. |
format | Online Article Text |
id | pubmed-3672805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36728052013-09-12 It takes two to tango in the microenvironment! Ursini-Siegel, Josie Park, Morag Breast Cancer Res Editorial Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E(2 )produced by epithelial cells and, in turn, promoted enhanced migration of epithelial cells. These events in epithelial cells in vitro, including telomere loss, heightened DNA damage response, and activin A expression, are observed in breast ductal carcinoma in situ lesions surrounded by stroma bearing hallmarks of activated fibroblasts and immune and endothelial cell infiltration. Thus, reciprocal epithelial-stromal interactions facilitate progression to malignancy and occur even at the earliest stages of mammary tumorigenesis. BioMed Central 2013 2013-03-12 /pmc/articles/PMC3672805/ /pubmed/23510134 http://dx.doi.org/10.1186/bcr3388 Text en Copyright © 2013 BioMed Central Ltd |
spellingShingle | Editorial Ursini-Siegel, Josie Park, Morag It takes two to tango in the microenvironment! |
title | It takes two to tango in the microenvironment! |
title_full | It takes two to tango in the microenvironment! |
title_fullStr | It takes two to tango in the microenvironment! |
title_full_unstemmed | It takes two to tango in the microenvironment! |
title_short | It takes two to tango in the microenvironment! |
title_sort | it takes two to tango in the microenvironment! |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672805/ https://www.ncbi.nlm.nih.gov/pubmed/23510134 http://dx.doi.org/10.1186/bcr3388 |
work_keys_str_mv | AT ursinisiegeljosie ittakestwototangointhemicroenvironment AT parkmorag ittakestwototangointhemicroenvironment |