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It takes two to tango in the microenvironment!

Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E(2 )produced by epithelial cells...

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Detalles Bibliográficos
Autores principales: Ursini-Siegel, Josie, Park, Morag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672805/
https://www.ncbi.nlm.nih.gov/pubmed/23510134
http://dx.doi.org/10.1186/bcr3388
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author Ursini-Siegel, Josie
Park, Morag
author_facet Ursini-Siegel, Josie
Park, Morag
author_sort Ursini-Siegel, Josie
collection PubMed
description Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E(2 )produced by epithelial cells and, in turn, promoted enhanced migration of epithelial cells. These events in epithelial cells in vitro, including telomere loss, heightened DNA damage response, and activin A expression, are observed in breast ductal carcinoma in situ lesions surrounded by stroma bearing hallmarks of activated fibroblasts and immune and endothelial cell infiltration. Thus, reciprocal epithelial-stromal interactions facilitate progression to malignancy and occur even at the earliest stages of mammary tumorigenesis.
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spelling pubmed-36728052013-09-12 It takes two to tango in the microenvironment! Ursini-Siegel, Josie Park, Morag Breast Cancer Res Editorial Using mortal non-tumorigenic human mammary epithelial cells and fibroblasts, Fordyce and colleagues show that an epithelial stress response promotes pro-tumorigenic changes in mammary fibroblasts. Fibroblast reprogramming was dependent on activin A or prostaglandin E(2 )produced by epithelial cells and, in turn, promoted enhanced migration of epithelial cells. These events in epithelial cells in vitro, including telomere loss, heightened DNA damage response, and activin A expression, are observed in breast ductal carcinoma in situ lesions surrounded by stroma bearing hallmarks of activated fibroblasts and immune and endothelial cell infiltration. Thus, reciprocal epithelial-stromal interactions facilitate progression to malignancy and occur even at the earliest stages of mammary tumorigenesis. BioMed Central 2013 2013-03-12 /pmc/articles/PMC3672805/ /pubmed/23510134 http://dx.doi.org/10.1186/bcr3388 Text en Copyright © 2013 BioMed Central Ltd
spellingShingle Editorial
Ursini-Siegel, Josie
Park, Morag
It takes two to tango in the microenvironment!
title It takes two to tango in the microenvironment!
title_full It takes two to tango in the microenvironment!
title_fullStr It takes two to tango in the microenvironment!
title_full_unstemmed It takes two to tango in the microenvironment!
title_short It takes two to tango in the microenvironment!
title_sort it takes two to tango in the microenvironment!
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672805/
https://www.ncbi.nlm.nih.gov/pubmed/23510134
http://dx.doi.org/10.1186/bcr3388
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