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Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients

INTRODUCTION: To investigate how markers of β-cell secretion (proinsulin-processing metabolites) are expressed in rheumatoid arthritis (RA) patients and their potential relation with the insulin resistance (IR) observed in these patients. METHODS: The 101 RA patients and 99 nondiabetic sex- and age-...

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Autores principales: Ferraz-Amaro, Iván, García-Dopico, Jose A, Medina-Vega, Lilian, González-Gay, Miguel A, Díaz-González, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672807/
https://www.ncbi.nlm.nih.gov/pubmed/23339356
http://dx.doi.org/10.1186/ar4149
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author Ferraz-Amaro, Iván
García-Dopico, Jose A
Medina-Vega, Lilian
González-Gay, Miguel A
Díaz-González, Federico
author_facet Ferraz-Amaro, Iván
García-Dopico, Jose A
Medina-Vega, Lilian
González-Gay, Miguel A
Díaz-González, Federico
author_sort Ferraz-Amaro, Iván
collection PubMed
description INTRODUCTION: To investigate how markers of β-cell secretion (proinsulin-processing metabolites) are expressed in rheumatoid arthritis (RA) patients and their potential relation with the insulin resistance (IR) observed in these patients. METHODS: The 101 RA patients and 99 nondiabetic sex- and age-matched controls were included. IR by homeostatic model assessment (HOMA2), and β-cell secretion, as measured by insulin, split and intact proinsulin, and C-peptide levels were determined for both groups. Multiple regression analysis was performed to compare IR between groups and to explore the interrelations between RA features, proinsulin metabolites, and IR. Data were adjusted for glucocorticoids intake and for IR classic risk factors. RESULTS: Compared with controls, RA patients showed higher HOMA-IR (β coef., 0.40 (95% CI, 0.20 to 0.59); P = 0.00). When data were adjusted for glucocorticoids intake, noncorticosteroid patients maintained a higher IR index (β, 0.14 (0.05 to 0.24); P = 0.00). Impaired insulin processing in RA patients was detected by the onset of elevated split proinsulin levels (β, 0.70 pmol/L (0.38 to 1.02); P = 0.00). These data remained significant also when adjusted for prednisone intake (β, 0.19 (0.00 to 0.36) pmol/L; P = 0.04). Split proinsulin-to-C-peptide ratios were higher in RA patients undergoing corticosteroid therapy (β, 0.25 (0.12 to 0.38); P = 0.03) and were nearly significant in comparison between noncorticosteroids patients and controls (β, 0.16 (-0.02 to 0.34); P = 0.08). Interestingly, the impact of HOMA-IR on the ratio of intact proinsulin to C-peptide was higher in controls compared with patients (β, 6.23 (1.41 to 11.06) versus 0.43 (-0.86 to 1.71); P = 0.03). CONCLUSIONS: β-Cell function is impaired in nondiabetic and in RA patients not taking corticoids by a mechanism that seems to be, at least in part, independent of IR.
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spelling pubmed-36728072013-06-10 Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients Ferraz-Amaro, Iván García-Dopico, Jose A Medina-Vega, Lilian González-Gay, Miguel A Díaz-González, Federico Arthritis Res Ther Research Article INTRODUCTION: To investigate how markers of β-cell secretion (proinsulin-processing metabolites) are expressed in rheumatoid arthritis (RA) patients and their potential relation with the insulin resistance (IR) observed in these patients. METHODS: The 101 RA patients and 99 nondiabetic sex- and age-matched controls were included. IR by homeostatic model assessment (HOMA2), and β-cell secretion, as measured by insulin, split and intact proinsulin, and C-peptide levels were determined for both groups. Multiple regression analysis was performed to compare IR between groups and to explore the interrelations between RA features, proinsulin metabolites, and IR. Data were adjusted for glucocorticoids intake and for IR classic risk factors. RESULTS: Compared with controls, RA patients showed higher HOMA-IR (β coef., 0.40 (95% CI, 0.20 to 0.59); P = 0.00). When data were adjusted for glucocorticoids intake, noncorticosteroid patients maintained a higher IR index (β, 0.14 (0.05 to 0.24); P = 0.00). Impaired insulin processing in RA patients was detected by the onset of elevated split proinsulin levels (β, 0.70 pmol/L (0.38 to 1.02); P = 0.00). These data remained significant also when adjusted for prednisone intake (β, 0.19 (0.00 to 0.36) pmol/L; P = 0.04). Split proinsulin-to-C-peptide ratios were higher in RA patients undergoing corticosteroid therapy (β, 0.25 (0.12 to 0.38); P = 0.03) and were nearly significant in comparison between noncorticosteroids patients and controls (β, 0.16 (-0.02 to 0.34); P = 0.08). Interestingly, the impact of HOMA-IR on the ratio of intact proinsulin to C-peptide was higher in controls compared with patients (β, 6.23 (1.41 to 11.06) versus 0.43 (-0.86 to 1.71); P = 0.03). CONCLUSIONS: β-Cell function is impaired in nondiabetic and in RA patients not taking corticoids by a mechanism that seems to be, at least in part, independent of IR. BioMed Central 2013 2013-01-22 /pmc/articles/PMC3672807/ /pubmed/23339356 http://dx.doi.org/10.1186/ar4149 Text en Copyright © 2013 Ferraz-Amaro et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ferraz-Amaro, Iván
García-Dopico, Jose A
Medina-Vega, Lilian
González-Gay, Miguel A
Díaz-González, Federico
Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
title Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
title_full Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
title_fullStr Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
title_full_unstemmed Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
title_short Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
title_sort impaired beta cell function is present in nondiabetic rheumatoid arthritis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672807/
https://www.ncbi.nlm.nih.gov/pubmed/23339356
http://dx.doi.org/10.1186/ar4149
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