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Crystal structure of Prp8 reveals active site cavity of the spliceosome

The active centre of the spliceosome consists of an intricate network formed by U5, U2 and U6 snRNAs, and a pre-mRNA substrate. Prp8, a component of the U5 snRNP, crosslinks extensively with this RNA catalytic core. We present the crystal structure of yeast Prp8 (residues 885-2413) in complex with t...

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Detalles Bibliográficos
Autores principales:	Galej, Wojciech P., Oubridge, Chris, Newman, Andrew J., Nagai, Kiyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672837/ https://www.ncbi.nlm.nih.gov/pubmed/23354046 http://dx.doi.org/10.1038/nature11843

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