T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses

Intestinal Peyer’s patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin (Ig) A production for gut homeostasis. Using IL-17 fate reporter mice we show here that endogenous T(H)17 cells in lymphoid organs of naïve mice home preferentially to the intestine and are...

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Autores principales: Hirota, Keiji, Turner, Jan-Eric, Villa, Matteo, Duarte, Joao H, Demengeot, Jocelyn, Steinmetz, Oliver M., Stockinger, Brigitta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672955/
https://www.ncbi.nlm.nih.gov/pubmed/23475182
http://dx.doi.org/10.1038/ni.2552
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author Hirota, Keiji
Turner, Jan-Eric
Villa, Matteo
Duarte, Joao H
Demengeot, Jocelyn
Steinmetz, Oliver M.
Stockinger, Brigitta
author_facet Hirota, Keiji
Turner, Jan-Eric
Villa, Matteo
Duarte, Joao H
Demengeot, Jocelyn
Steinmetz, Oliver M.
Stockinger, Brigitta
author_sort Hirota, Keiji
collection PubMed
description Intestinal Peyer’s patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin (Ig) A production for gut homeostasis. Using IL-17 fate reporter mice we show here that endogenous T(H)17 cells in lymphoid organs of naïve mice home preferentially to the intestine and are maintained independently of IL-23. In Peyer’s patches such T(H)17 cells acquire a T follicular helper (T(FH)) phenotype and induce the development of IgA-producing germinal center B cells. Mice deficient in T(H)17 cells fail to generate antigen specific IgA responses, providing evidence that T(H)17 cells are the crucial subset required for high affinity T cell-dependent IgA production.
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spelling pubmed-36729552013-10-01 T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses Hirota, Keiji Turner, Jan-Eric Villa, Matteo Duarte, Joao H Demengeot, Jocelyn Steinmetz, Oliver M. Stockinger, Brigitta Nat Immunol Article Intestinal Peyer’s patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin (Ig) A production for gut homeostasis. Using IL-17 fate reporter mice we show here that endogenous T(H)17 cells in lymphoid organs of naïve mice home preferentially to the intestine and are maintained independently of IL-23. In Peyer’s patches such T(H)17 cells acquire a T follicular helper (T(FH)) phenotype and induce the development of IgA-producing germinal center B cells. Mice deficient in T(H)17 cells fail to generate antigen specific IgA responses, providing evidence that T(H)17 cells are the crucial subset required for high affinity T cell-dependent IgA production. 2013-03-10 2013-04 /pmc/articles/PMC3672955/ /pubmed/23475182 http://dx.doi.org/10.1038/ni.2552 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hirota, Keiji
Turner, Jan-Eric
Villa, Matteo
Duarte, Joao H
Demengeot, Jocelyn
Steinmetz, Oliver M.
Stockinger, Brigitta
T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses
title T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses
title_full T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses
title_fullStr T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses
title_full_unstemmed T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses
title_short T(H)17 cell plasticity in Peyer’s patches is responsible for induction of T cell-dependent IgA responses
title_sort t(h)17 cell plasticity in peyer’s patches is responsible for induction of t cell-dependent iga responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672955/
https://www.ncbi.nlm.nih.gov/pubmed/23475182
http://dx.doi.org/10.1038/ni.2552
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