Intracellular antibody-bound pathogens stimulate immune signaling via Fc-receptor TRIM21

Antibodies can be carried into the cell during pathogen infection where they are detected by the ubiquitously expressed cytosolic antibody receptor TRIM21. Here we show that TRIM21 recognition of intracellular antibodies activates immune signaling. TRIM21 catalyses K63-ubiquitin chain formation, sti...

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Detalles Bibliográficos
Autores principales: McEwan, W.A, Tam, J.C.H, Watkinson, R.E, Bidgood, S.R, Mallery, D.L, James, L.C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672961/
https://www.ncbi.nlm.nih.gov/pubmed/23455675
http://dx.doi.org/10.1038/ni.2548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672961/
https://www.ncbi.nlm.nih.gov/pubmed/23455675
http://dx.doi.org/10.1038/ni.2548

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