Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes

The rates of escape and reversion in response to selection pressure arising from the host immune system, notably the cytotoxic T-lymphocyte (CTL) response, are key factors determining the evolution of HIV. Existing methods for estimating these parameters from cross-sectional population data using or...

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Detalles Bibliográficos
Autores principales: Palmer, Duncan, Frater, John, Phillips, Rodney, McLean, Angela R., McVean, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673055/
https://www.ncbi.nlm.nih.gov/pubmed/23677344
http://dx.doi.org/10.1098/rspb.2013.0696

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