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Caffeine as a Potential Quorum Sensing Inhibitor

Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of...

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Autores principales: Norizan, Siti Nur Maisarah, Yin, Wai-Fong, Chan, Kok-Gan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673129/
https://www.ncbi.nlm.nih.gov/pubmed/23598500
http://dx.doi.org/10.3390/s130405117
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author Norizan, Siti Nur Maisarah
Yin, Wai-Fong
Chan, Kok-Gan
author_facet Norizan, Siti Nur Maisarah
Yin, Wai-Fong
Chan, Kok-Gan
author_sort Norizan, Siti Nur Maisarah
collection PubMed
description Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of quorum sensing inhibitor would be of particular interest in treating bacterial pathogenicity and infections. In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor. We verified that caffeine did not degrade the N-acyl homoserine lactones tested. In this work, it is shown that caffeine could inhibit N-acyl homoserine lactone production and swarming of a human opportunistic pathogen, namely Pseudomonas aeruginosa PA01. To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs.
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spelling pubmed-36731292013-06-19 Caffeine as a Potential Quorum Sensing Inhibitor Norizan, Siti Nur Maisarah Yin, Wai-Fong Chan, Kok-Gan Sensors (Basel) Article Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of quorum sensing inhibitor would be of particular interest in treating bacterial pathogenicity and infections. In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor. We verified that caffeine did not degrade the N-acyl homoserine lactones tested. In this work, it is shown that caffeine could inhibit N-acyl homoserine lactone production and swarming of a human opportunistic pathogen, namely Pseudomonas aeruginosa PA01. To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs. Molecular Diversity Preservation International (MDPI) 2013-04-18 /pmc/articles/PMC3673129/ /pubmed/23598500 http://dx.doi.org/10.3390/s130405117 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Norizan, Siti Nur Maisarah
Yin, Wai-Fong
Chan, Kok-Gan
Caffeine as a Potential Quorum Sensing Inhibitor
title Caffeine as a Potential Quorum Sensing Inhibitor
title_full Caffeine as a Potential Quorum Sensing Inhibitor
title_fullStr Caffeine as a Potential Quorum Sensing Inhibitor
title_full_unstemmed Caffeine as a Potential Quorum Sensing Inhibitor
title_short Caffeine as a Potential Quorum Sensing Inhibitor
title_sort caffeine as a potential quorum sensing inhibitor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673129/
https://www.ncbi.nlm.nih.gov/pubmed/23598500
http://dx.doi.org/10.3390/s130405117
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