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Caffeine as a Potential Quorum Sensing Inhibitor
Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673129/ https://www.ncbi.nlm.nih.gov/pubmed/23598500 http://dx.doi.org/10.3390/s130405117 |
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author | Norizan, Siti Nur Maisarah Yin, Wai-Fong Chan, Kok-Gan |
author_facet | Norizan, Siti Nur Maisarah Yin, Wai-Fong Chan, Kok-Gan |
author_sort | Norizan, Siti Nur Maisarah |
collection | PubMed |
description | Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of quorum sensing inhibitor would be of particular interest in treating bacterial pathogenicity and infections. In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor. We verified that caffeine did not degrade the N-acyl homoserine lactones tested. In this work, it is shown that caffeine could inhibit N-acyl homoserine lactone production and swarming of a human opportunistic pathogen, namely Pseudomonas aeruginosa PA01. To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs. |
format | Online Article Text |
id | pubmed-3673129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-36731292013-06-19 Caffeine as a Potential Quorum Sensing Inhibitor Norizan, Siti Nur Maisarah Yin, Wai-Fong Chan, Kok-Gan Sensors (Basel) Article Quorum sensing enables bacteria to control the gene expression in response to the cell density. It regulates a variety of bacterial physiological functions such as biofilm formation, bioluminescence, virulence factors and swarming which has been shown contribute to bacterial pathogenesis. The use of quorum sensing inhibitor would be of particular interest in treating bacterial pathogenicity and infections. In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor. We verified that caffeine did not degrade the N-acyl homoserine lactones tested. In this work, it is shown that caffeine could inhibit N-acyl homoserine lactone production and swarming of a human opportunistic pathogen, namely Pseudomonas aeruginosa PA01. To the best of our knowledge, this is the first documentation providing evidence on the presence of anti-quorum sensing activity in caffeine. Our work will allow caffeine to be explored as anti-infective drugs. Molecular Diversity Preservation International (MDPI) 2013-04-18 /pmc/articles/PMC3673129/ /pubmed/23598500 http://dx.doi.org/10.3390/s130405117 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Norizan, Siti Nur Maisarah Yin, Wai-Fong Chan, Kok-Gan Caffeine as a Potential Quorum Sensing Inhibitor |
title | Caffeine as a Potential Quorum Sensing Inhibitor |
title_full | Caffeine as a Potential Quorum Sensing Inhibitor |
title_fullStr | Caffeine as a Potential Quorum Sensing Inhibitor |
title_full_unstemmed | Caffeine as a Potential Quorum Sensing Inhibitor |
title_short | Caffeine as a Potential Quorum Sensing Inhibitor |
title_sort | caffeine as a potential quorum sensing inhibitor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673129/ https://www.ncbi.nlm.nih.gov/pubmed/23598500 http://dx.doi.org/10.3390/s130405117 |
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