Cargando…
In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort
Background: In utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life. Objectives: The Center for the Health Assessment of Mothers and Children of Sali...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673191/ https://www.ncbi.nlm.nih.gov/pubmed/23512307 http://dx.doi.org/10.1289/ehp.1205656 |
_version_ | 1782272222959763456 |
---|---|
author | Warner, Marcella Schall, Raul Aguilar Harley, Kim G. Bradman, Asa Barr, Dana Eskenazi, Brenda |
author_facet | Warner, Marcella Schall, Raul Aguilar Harley, Kim G. Bradman, Asa Barr, Dana Eskenazi, Brenda |
author_sort | Warner, Marcella |
collection | PubMed |
description | Background: In utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life. Objectives: The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study is a longitudinal birth cohort of low-income Latinas living in a California agricultural community. We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age. We also examined the trend with age (2, 3.5, 5, and 7 years) in the exposure–obesity relation. Methods: We included 270 children with o,p´-DDT, p,p´-DDT, and p,p´-DDE concentrations measured in maternal serum during pregnancy (nanograms per gram lipid) and complete 7-year follow-up data including weight (kilograms) and height (centimeters). Body mass index (BMI; kilograms per meter squared) was calculated and obesity was defined as ≥ 95th percentile on the sex-specific BMI-for-age Centers for Disease Control and Prevention 2000 growth charts. Results: At 7 years, 96 (35.6%) children were obese. A 10-fold increase in o,p´-DDT, p,p´-DDT, or p,p´-DDE, was nonsignificantly associated with increased odds (OR) of obesity [o,p´-DDT adjusted (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p´-DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p´-DDE adj-OR = 1.22, 95% CI: 0.72, 2.06]. With increasing age at follow-up, we observed a significant trend toward a positive association between DDT and DDE exposure and odds of obesity. Conclusion: We did not find a significant positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old children. However, given the observed trend with age, continued follow-up will be informative. |
format | Online Article Text |
id | pubmed-3673191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-36731912013-06-18 In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort Warner, Marcella Schall, Raul Aguilar Harley, Kim G. Bradman, Asa Barr, Dana Eskenazi, Brenda Environ Health Perspect Research Background: In utero exposure to endocrine disrupting compounds including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity later in life. Objectives: The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study is a longitudinal birth cohort of low-income Latinas living in a California agricultural community. We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age. We also examined the trend with age (2, 3.5, 5, and 7 years) in the exposure–obesity relation. Methods: We included 270 children with o,p´-DDT, p,p´-DDT, and p,p´-DDE concentrations measured in maternal serum during pregnancy (nanograms per gram lipid) and complete 7-year follow-up data including weight (kilograms) and height (centimeters). Body mass index (BMI; kilograms per meter squared) was calculated and obesity was defined as ≥ 95th percentile on the sex-specific BMI-for-age Centers for Disease Control and Prevention 2000 growth charts. Results: At 7 years, 96 (35.6%) children were obese. A 10-fold increase in o,p´-DDT, p,p´-DDT, or p,p´-DDE, was nonsignificantly associated with increased odds (OR) of obesity [o,p´-DDT adjusted (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p´-DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p´-DDE adj-OR = 1.22, 95% CI: 0.72, 2.06]. With increasing age at follow-up, we observed a significant trend toward a positive association between DDT and DDE exposure and odds of obesity. Conclusion: We did not find a significant positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old children. However, given the observed trend with age, continued follow-up will be informative. National Institute of Environmental Health Sciences 2013-03-19 2013-05 /pmc/articles/PMC3673191/ /pubmed/23512307 http://dx.doi.org/10.1289/ehp.1205656 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Warner, Marcella Schall, Raul Aguilar Harley, Kim G. Bradman, Asa Barr, Dana Eskenazi, Brenda In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort |
title | In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort |
title_full | In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort |
title_fullStr | In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort |
title_full_unstemmed | In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort |
title_short | In Utero DDT and DDE Exposure and Obesity Status of 7-Year-Old Mexican-American Children in the CHAMACOS Cohort |
title_sort | in utero ddt and dde exposure and obesity status of 7-year-old mexican-american children in the chamacos cohort |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673191/ https://www.ncbi.nlm.nih.gov/pubmed/23512307 http://dx.doi.org/10.1289/ehp.1205656 |
work_keys_str_mv | AT warnermarcella inuteroddtandddeexposureandobesitystatusof7yearoldmexicanamericanchildreninthechamacoscohort AT schallraulaguilar inuteroddtandddeexposureandobesitystatusof7yearoldmexicanamericanchildreninthechamacoscohort AT harleykimg inuteroddtandddeexposureandobesitystatusof7yearoldmexicanamericanchildreninthechamacoscohort AT bradmanasa inuteroddtandddeexposureandobesitystatusof7yearoldmexicanamericanchildreninthechamacoscohort AT barrdana inuteroddtandddeexposureandobesitystatusof7yearoldmexicanamericanchildreninthechamacoscohort AT eskenazibrenda inuteroddtandddeexposureandobesitystatusof7yearoldmexicanamericanchildreninthechamacoscohort |