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Gene Conversion Shapes Linear Mitochondrial Genome Architecture
Recently, it was shown that gene conversion between the ends of linear mitochondrial chromosomes can cause telomere expansion and the duplication of subtelomeric loci. However, it is not yet known how widespread this phenomenon is and how significantly it has impacted organelle genome architecture....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673629/ https://www.ncbi.nlm.nih.gov/pubmed/23572386 http://dx.doi.org/10.1093/gbe/evt059 |
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author | Smith, David Roy Keeling, Patrick J. |
author_facet | Smith, David Roy Keeling, Patrick J. |
author_sort | Smith, David Roy |
collection | PubMed |
description | Recently, it was shown that gene conversion between the ends of linear mitochondrial chromosomes can cause telomere expansion and the duplication of subtelomeric loci. However, it is not yet known how widespread this phenomenon is and how significantly it has impacted organelle genome architecture. Using linear mitochondrial DNAs and mitochondrial plasmids from diverse eukaryotes, we argue that telomeric recombination has played a major role in fashioning linear organelle chromosomes. We find that mitochondrial telomeres frequently expand into subtelomeric regions, resulting in gene duplications, homogenizations, and/or fragmentations. We suggest that these features are a product of subtelomeric gene conversion, provide a hypothetical model for this process, and employ genetic diversity data to support the idea that the greater the effective population size the greater the potential for gene conversion between subtelomeric loci. |
format | Online Article Text |
id | pubmed-3673629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36736292013-06-05 Gene Conversion Shapes Linear Mitochondrial Genome Architecture Smith, David Roy Keeling, Patrick J. Genome Biol Evol Letter Recently, it was shown that gene conversion between the ends of linear mitochondrial chromosomes can cause telomere expansion and the duplication of subtelomeric loci. However, it is not yet known how widespread this phenomenon is and how significantly it has impacted organelle genome architecture. Using linear mitochondrial DNAs and mitochondrial plasmids from diverse eukaryotes, we argue that telomeric recombination has played a major role in fashioning linear organelle chromosomes. We find that mitochondrial telomeres frequently expand into subtelomeric regions, resulting in gene duplications, homogenizations, and/or fragmentations. We suggest that these features are a product of subtelomeric gene conversion, provide a hypothetical model for this process, and employ genetic diversity data to support the idea that the greater the effective population size the greater the potential for gene conversion between subtelomeric loci. Oxford University Press 2013 2013-04-09 /pmc/articles/PMC3673629/ /pubmed/23572386 http://dx.doi.org/10.1093/gbe/evt059 Text en © The Author(s) 2013. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Letter Smith, David Roy Keeling, Patrick J. Gene Conversion Shapes Linear Mitochondrial Genome Architecture |
title | Gene Conversion Shapes Linear Mitochondrial Genome Architecture |
title_full | Gene Conversion Shapes Linear Mitochondrial Genome Architecture |
title_fullStr | Gene Conversion Shapes Linear Mitochondrial Genome Architecture |
title_full_unstemmed | Gene Conversion Shapes Linear Mitochondrial Genome Architecture |
title_short | Gene Conversion Shapes Linear Mitochondrial Genome Architecture |
title_sort | gene conversion shapes linear mitochondrial genome architecture |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673629/ https://www.ncbi.nlm.nih.gov/pubmed/23572386 http://dx.doi.org/10.1093/gbe/evt059 |
work_keys_str_mv | AT smithdavidroy geneconversionshapeslinearmitochondrialgenomearchitecture AT keelingpatrickj geneconversionshapeslinearmitochondrialgenomearchitecture |