Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression

Molecular mechanisms regulating TGF-β induction of Foxp3 expression and thus induction of iTregs has been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as perhaps might be predicted by the fact that there is an overarch...

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Detalles Bibliográficos
Autores principales: Xu, Lili, Kitani, Atsushi, Strober, Warren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673708/
https://www.ncbi.nlm.nih.gov/pubmed/20404810
http://dx.doi.org/10.1038/mi.2010.7
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author Xu, Lili
Kitani, Atsushi
Strober, Warren
author_facet Xu, Lili
Kitani, Atsushi
Strober, Warren
author_sort Xu, Lili
collection PubMed
description Molecular mechanisms regulating TGF-β induction of Foxp3 expression and thus induction of iTregs has been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as perhaps might be predicted by the fact that there is an overarching need of the immune system to fine-tune response to environmental antigens. In this review we discuss these mechanisms, with the aim of presenting a broad picture of how the various observations fit together to form an integrated regulatory regime.
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spelling pubmed-36737082013-06-05 Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression Xu, Lili Kitani, Atsushi Strober, Warren Mucosal Immunol Article Molecular mechanisms regulating TGF-β induction of Foxp3 expression and thus induction of iTregs has been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as perhaps might be predicted by the fact that there is an overarching need of the immune system to fine-tune response to environmental antigens. In this review we discuss these mechanisms, with the aim of presenting a broad picture of how the various observations fit together to form an integrated regulatory regime. 2010-03-10 2010-05 /pmc/articles/PMC3673708/ /pubmed/20404810 http://dx.doi.org/10.1038/mi.2010.7 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Xu, Lili
Kitani, Atsushi
Strober, Warren
Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
title Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
title_full Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
title_fullStr Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
title_full_unstemmed Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
title_short Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
title_sort molecular mechanisms regulating tgf-β-induced foxp3 expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673708/
https://www.ncbi.nlm.nih.gov/pubmed/20404810
http://dx.doi.org/10.1038/mi.2010.7
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