3,4-dihydroxyphenyl acetic acid and (+)-epoxydon isolated from marine algae-derived microorganisms induce down regulation of epidermal growth factor activated mitogenic signaling cascade in Hela cells

BACKGROUND: Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase (RTK) family. Epidermal growth factor induces its dimerization and stimulates phosphorylation of intracellular tyrosine residues. Phosphorylation of EGFR is studied for cancer therapy because EGFR regulat...

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Detalles Bibliográficos
Autores principales: Jo, Mi Jeong, Bae, Seong Ja, Son, Byeng Wha, Kim, Chi Yeon, Kim, Gun Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673896/
https://www.ncbi.nlm.nih.gov/pubmed/23706036
http://dx.doi.org/10.1186/1475-2867-13-49

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