Small Molecule R1498 as a Well-Tolerated and Orally Active Kinase Inhibitor for Hepatocellular Carcinoma and Gastric Cancer Treatment via Targeting Angiogenesis and Mitosis Pathways

Protein kinases play important roles in tumor development and progression. Lots of kinase inhibitors have entered into market and show promising clinical benefits. Here we report the discovery of a novel small molecule, well-tolerated, orally active kinase inhibitor, R1498, majorly targeting both an...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Wu, Xihan, Zhang, Meifang, Zhu, Liangcheng, Zhao, Rong, Xu, Danqing, Lin, Zhaohu, Liang, Chungen, Chen, Taiping, Chen, Li, Ren, Yi, Zhang, Joe, Qin, Ning, Zhang, Xiongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673949/
https://www.ncbi.nlm.nih.gov/pubmed/23755206
http://dx.doi.org/10.1371/journal.pone.0065264

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