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Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis

BACKGROUND: Acanthamoeba keratitis (AK) is ever more frequently reported in industrialized countries. The loss of the corneal surface integrity consequent to secondary microtrauma produced by the use of contact lens (CL) favors the penetration of the parasite into the corneal tissue. OBJECTIVES: A s...

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Autores principales: Pacella, Elena, La Torre, Giuseppe, De Giusti, Maria, Brillante, Chiara, Lombardi, Anna Maria, Smaldone, Gianpaolo, Lenzi, Tommaso, Pacella, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673962/
https://www.ncbi.nlm.nih.gov/pubmed/23761962
http://dx.doi.org/10.2147/OPTH.S43471
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author Pacella, Elena
La Torre, Giuseppe
De Giusti, Maria
Brillante, Chiara
Lombardi, Anna Maria
Smaldone, Gianpaolo
Lenzi, Tommaso
Pacella, Fernanda
author_facet Pacella, Elena
La Torre, Giuseppe
De Giusti, Maria
Brillante, Chiara
Lombardi, Anna Maria
Smaldone, Gianpaolo
Lenzi, Tommaso
Pacella, Fernanda
author_sort Pacella, Elena
collection PubMed
description BACKGROUND: Acanthamoeba keratitis (AK) is ever more frequently reported in industrialized countries. The loss of the corneal surface integrity consequent to secondary microtrauma produced by the use of contact lens (CL) favors the penetration of the parasite into the corneal tissue. OBJECTIVES: A scientific review was performed to investigate the association of CL wear as an Acanthamoeba keratitis (AK) risk factor. METHODS: A computerized screening of 7834 Medline articles (4623 from PubMed; 3211 from Scopus) used a strict selection criteria of case-control studies involving CL wear and/or trauma. RESULTS: The search yielded five case-control studies published from 1995 to 2012. All studies included showed a statistically significant positive association between AK and CL use, with a combined odds ratio (OR) of 10.21 (95%, confidence intervals [CI]; 3.57–27.64). STATISTICAL ANALYSIS: All studies included showed a statistically significant positive association between AK and CL use, though with differing OR values. CONCLUSION: Though rare, AK should be held in higher consideration when ophthalmologists are faced with CL users exhibiting simplex-like lesions associated with circular stromal infiltrates and disproportionate ocular pain in respect to the objective clinical picture.
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spelling pubmed-36739622013-06-12 Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis Pacella, Elena La Torre, Giuseppe De Giusti, Maria Brillante, Chiara Lombardi, Anna Maria Smaldone, Gianpaolo Lenzi, Tommaso Pacella, Fernanda Clin Ophthalmol Review BACKGROUND: Acanthamoeba keratitis (AK) is ever more frequently reported in industrialized countries. The loss of the corneal surface integrity consequent to secondary microtrauma produced by the use of contact lens (CL) favors the penetration of the parasite into the corneal tissue. OBJECTIVES: A scientific review was performed to investigate the association of CL wear as an Acanthamoeba keratitis (AK) risk factor. METHODS: A computerized screening of 7834 Medline articles (4623 from PubMed; 3211 from Scopus) used a strict selection criteria of case-control studies involving CL wear and/or trauma. RESULTS: The search yielded five case-control studies published from 1995 to 2012. All studies included showed a statistically significant positive association between AK and CL use, with a combined odds ratio (OR) of 10.21 (95%, confidence intervals [CI]; 3.57–27.64). STATISTICAL ANALYSIS: All studies included showed a statistically significant positive association between AK and CL use, though with differing OR values. CONCLUSION: Though rare, AK should be held in higher consideration when ophthalmologists are faced with CL users exhibiting simplex-like lesions associated with circular stromal infiltrates and disproportionate ocular pain in respect to the objective clinical picture. Dove Medical Press 2013 2013-05-28 /pmc/articles/PMC3673962/ /pubmed/23761962 http://dx.doi.org/10.2147/OPTH.S43471 Text en © 2013 Pacella et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Pacella, Elena
La Torre, Giuseppe
De Giusti, Maria
Brillante, Chiara
Lombardi, Anna Maria
Smaldone, Gianpaolo
Lenzi, Tommaso
Pacella, Fernanda
Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis
title Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis
title_full Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis
title_fullStr Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis
title_full_unstemmed Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis
title_short Results of case-control studies support the association between contact lens use and Acanthamoeba keratitis
title_sort results of case-control studies support the association between contact lens use and acanthamoeba keratitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673962/
https://www.ncbi.nlm.nih.gov/pubmed/23761962
http://dx.doi.org/10.2147/OPTH.S43471
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