Cargando…
A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite
Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphro...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674237/ https://www.ncbi.nlm.nih.gov/pubmed/23652002 http://dx.doi.org/10.1038/ncomms2811 |
_version_ | 1782272330379034624 |
---|---|
author | Chong, Tracy Collins, James J. Brubacher, John L. Zarkower, David Newmark, Phillip A. |
author_facet | Chong, Tracy Collins, James J. Brubacher, John L. Zarkower, David Newmark, Phillip A. |
author_sort | Chong, Tracy |
collection | PubMed |
description | Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphrodites specify and maintain male and female organs in a single individual. Here we show that a sex-specific gene, Smed-dmd-1 encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian Schmidtea mediterranea. dmd-1 has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of dmd-1 exhibits male-specific expression in Schistosoma mansoni, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy. |
format | Online Article Text |
id | pubmed-3674237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36742372013-06-06 A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite Chong, Tracy Collins, James J. Brubacher, John L. Zarkower, David Newmark, Phillip A. Nat Commun Article Evolutionary transitions between hermaphroditic and dioecious reproductive states are found in many groups of animals. To understand such transitions, it is important to characterize diverse modes of sex determination utilized by metazoans. Currently, little is known about how simultaneous hermaphrodites specify and maintain male and female organs in a single individual. Here we show that a sex-specific gene, Smed-dmd-1 encoding a predicted doublesex/male-abnormal-3 (DM) domain transcription factor, is required for specification of male germ cells in a simultaneous hermaphrodite, the planarian Schmidtea mediterranea. dmd-1 has a male-specific role in the maintenance and regeneration of the testes and male accessory reproductive organs. In addition, a homologue of dmd-1 exhibits male-specific expression in Schistosoma mansoni, a derived, dioecious flatworm. These results demonstrate conservation of the role of DM domain genes in sexual development in lophotrochozoans and suggest one means by which modulation of sex-specific pathways can drive the transition from hermaphroditism to dioecy. Nature Pub. Group 2013-05-07 /pmc/articles/PMC3674237/ /pubmed/23652002 http://dx.doi.org/10.1038/ncomms2811 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Chong, Tracy Collins, James J. Brubacher, John L. Zarkower, David Newmark, Phillip A. A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
title | A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
title_full | A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
title_fullStr | A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
title_full_unstemmed | A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
title_short | A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
title_sort | sex-specific transcription factor controls male identity in a simultaneous hermaphrodite |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674237/ https://www.ncbi.nlm.nih.gov/pubmed/23652002 http://dx.doi.org/10.1038/ncomms2811 |
work_keys_str_mv | AT chongtracy asexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT collinsjamesj asexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT brubacherjohnl asexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT zarkowerdavid asexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT newmarkphillipa asexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT chongtracy sexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT collinsjamesj sexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT brubacherjohnl sexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT zarkowerdavid sexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite AT newmarkphillipa sexspecifictranscriptionfactorcontrolsmaleidentityinasimultaneoushermaphrodite |