Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin–p...

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Detalles Bibliográficos
Autores principales: Lignitto, Luca, Arcella, Antonietta, Sepe, Maria, Rinaldi, Laura, Delle Donne, Rossella, Gallo, Adriana, Stefan, Eduard, Bachmann, Verena A., Oliva, Maria A., Tiziana Storlazzi, Clelia, L'Abbate, Alberto, Brunetti, Arturo, Gargiulo, Sara, Gramanzini, Matteo, Insabato, Luigi, Garbi, Corrado, Gottesman, Max E., Feliciello, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674242/
https://www.ncbi.nlm.nih.gov/pubmed/23652010
http://dx.doi.org/10.1038/ncomms2791

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