Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

A de novo G608G mutation in LMNA gene leads to Hutchinson–Gilford progeria syndrome. Mice lacking the prelamin A-processing metalloprotease, Zmpste24, recapitulate many of the progeroid features of Hutchinson–Gilford progeria syndrome. Here we show that A-type lamins interact with SUV39H1, and prela...

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Detalles Bibliográficos
Autores principales: Liu, Baohua, Wang, Zimei, Zhang, Le, Ghosh, Shrestha, Zheng, Huiling, Zhou, Zhongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674265/
https://www.ncbi.nlm.nih.gov/pubmed/23695662
http://dx.doi.org/10.1038/ncomms2885

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