NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

Human APOBEC3A (A3A) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts viral pathogens and endogenous retrotransposons and plays a role in the innate immune response. Furthermore, its potential to act as a genomic DNA mutator has implications for a role in carcinogenesis. A deeper u...

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Detalles Bibliográficos
Autores principales: Byeon, In-Ja L., Ahn, Jinwoo, Mitra, Mithun, Byeon, Chang-Hyeock, Hercík, Kamil, Hritz, Jozef, Charlton, Lisa M., Levin, Judith G., Gronenborn, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674325/
https://www.ncbi.nlm.nih.gov/pubmed/23695684
http://dx.doi.org/10.1038/ncomms2883

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