Cargando…

Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis

OBJECTIVES: We investigated the relationship between white-matter alteration and cognitive status in Parkinson’s disease (PD) with and without dementia by using diffusion tensor imaging. METHODS: Twenty PD patients, 20 PDD (Parkinson’s disease with dementia) patients and 20 age-matched healthy contr...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamagata, Koji, Motoi, Yumiko, Tomiyama, Hiroyuki, Abe, Osamu, Ito, Kenji, Shimoji, Keigo, Suzuki, Michimasa, Hori, Masaaki, Nakanishi, Atsushi, Sano, Tamotsu, Kuwatsuru, Ryohei, Sasai, Keisuke, Aoki, Shigeki, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674338/
https://www.ncbi.nlm.nih.gov/pubmed/23404139
http://dx.doi.org/10.1007/s00330-013-2775-4
_version_ 1782272355253354496
author Kamagata, Koji
Motoi, Yumiko
Tomiyama, Hiroyuki
Abe, Osamu
Ito, Kenji
Shimoji, Keigo
Suzuki, Michimasa
Hori, Masaaki
Nakanishi, Atsushi
Sano, Tamotsu
Kuwatsuru, Ryohei
Sasai, Keisuke
Aoki, Shigeki
Hattori, Nobutaka
author_facet Kamagata, Koji
Motoi, Yumiko
Tomiyama, Hiroyuki
Abe, Osamu
Ito, Kenji
Shimoji, Keigo
Suzuki, Michimasa
Hori, Masaaki
Nakanishi, Atsushi
Sano, Tamotsu
Kuwatsuru, Ryohei
Sasai, Keisuke
Aoki, Shigeki
Hattori, Nobutaka
author_sort Kamagata, Koji
collection PubMed
description OBJECTIVES: We investigated the relationship between white-matter alteration and cognitive status in Parkinson’s disease (PD) with and without dementia by using diffusion tensor imaging. METHODS: Twenty PD patients, 20 PDD (Parkinson’s disease with dementia) patients and 20 age-matched healthy controls underwent diffusion tensor imaging. The mean diffusivity and fractional anisotropy (FA) map of each patient group were compared with those of the control group by using tract-based spatial statistics. Tractography images of the genu of the corpus callosum fibre tracts were generated, and mean diffusivity and FA were measured. RESULTS: FA values in many major tracts were significantly lower in PDD patients than in control subjects; in the prefrontal white matter and the genu of the corpus callosum they were significantly lower in PDD patients than in PD patients. There was a significant correlation between the Mini-Mental State Examination (MMSE) scores and the FA values of the prefrontal white matter and the genu of the corpus callosum in patients with PD. CONCLUSIONS: Our study shows a relationship between cognitive impairment and alteration of the prefrontal white matter and genu of the corpus callosum. These changes may be useful in assessing the onset of dementia in PD patients. KEY POINTS: • Dementia is a common and important non-motor sign of Parkinson’s disease (PD). • The neuropathological basis of dementia in PD is not clear. • DTI shows abnormalities in the prefrontal white matter in PD with dementia. • Prefrontal white matter alteration may be useful biomarker of dementia in PD.
format Online
Article
Text
id pubmed-3674338
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-36743382013-06-10 Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis Kamagata, Koji Motoi, Yumiko Tomiyama, Hiroyuki Abe, Osamu Ito, Kenji Shimoji, Keigo Suzuki, Michimasa Hori, Masaaki Nakanishi, Atsushi Sano, Tamotsu Kuwatsuru, Ryohei Sasai, Keisuke Aoki, Shigeki Hattori, Nobutaka Eur Radiol Neuro OBJECTIVES: We investigated the relationship between white-matter alteration and cognitive status in Parkinson’s disease (PD) with and without dementia by using diffusion tensor imaging. METHODS: Twenty PD patients, 20 PDD (Parkinson’s disease with dementia) patients and 20 age-matched healthy controls underwent diffusion tensor imaging. The mean diffusivity and fractional anisotropy (FA) map of each patient group were compared with those of the control group by using tract-based spatial statistics. Tractography images of the genu of the corpus callosum fibre tracts were generated, and mean diffusivity and FA were measured. RESULTS: FA values in many major tracts were significantly lower in PDD patients than in control subjects; in the prefrontal white matter and the genu of the corpus callosum they were significantly lower in PDD patients than in PD patients. There was a significant correlation between the Mini-Mental State Examination (MMSE) scores and the FA values of the prefrontal white matter and the genu of the corpus callosum in patients with PD. CONCLUSIONS: Our study shows a relationship between cognitive impairment and alteration of the prefrontal white matter and genu of the corpus callosum. These changes may be useful in assessing the onset of dementia in PD patients. KEY POINTS: • Dementia is a common and important non-motor sign of Parkinson’s disease (PD). • The neuropathological basis of dementia in PD is not clear. • DTI shows abnormalities in the prefrontal white matter in PD with dementia. • Prefrontal white matter alteration may be useful biomarker of dementia in PD. Springer-Verlag 2013-02-13 2013 /pmc/articles/PMC3674338/ /pubmed/23404139 http://dx.doi.org/10.1007/s00330-013-2775-4 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.5/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Neuro
Kamagata, Koji
Motoi, Yumiko
Tomiyama, Hiroyuki
Abe, Osamu
Ito, Kenji
Shimoji, Keigo
Suzuki, Michimasa
Hori, Masaaki
Nakanishi, Atsushi
Sano, Tamotsu
Kuwatsuru, Ryohei
Sasai, Keisuke
Aoki, Shigeki
Hattori, Nobutaka
Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
title Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
title_full Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
title_fullStr Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
title_full_unstemmed Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
title_short Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
title_sort relationship between cognitive impairment and white-matter alteration in parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis
topic Neuro
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674338/
https://www.ncbi.nlm.nih.gov/pubmed/23404139
http://dx.doi.org/10.1007/s00330-013-2775-4
work_keys_str_mv AT kamagatakoji relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT motoiyumiko relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT tomiyamahiroyuki relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT abeosamu relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT itokenji relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT shimojikeigo relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT suzukimichimasa relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT horimasaaki relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT nakanishiatsushi relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT sanotamotsu relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT kuwatsururyohei relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT sasaikeisuke relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT aokishigeki relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis
AT hattorinobutaka relationshipbetweencognitiveimpairmentandwhitematteralterationinparkinsonsdiseasewithdementiatractbasedspatialstatisticsandtractspecificanalysis