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BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells

The purine analog fludarabine (Fd) is an essential therapeutic for chronic lymphocytic leukemia (CLL). Innate or acquired resistance to Fd is a significant clinical problem and is largely mediated by increased expression of BCL-2 family members. The antiapoptotic BCL-2 family proteins inhibit both a...

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Detalles Bibliográficos
Autores principales:	Sharma, A, Singh, K, Mazumder, S, Hill, B T, Kalaycio, M, Almasan, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674362/ https://www.ncbi.nlm.nih.gov/pubmed/23681223 http://dx.doi.org/10.1038/cddis.2013.155

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