Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cells

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The nitrogen-containing bisphosphonates (N-BP) zoledronic acid (ZOL) inhibits osteoclast-mediated bone resorption, and it is used to prevent skeletal complications from bone metastases. ZOL has also demonstrated anticancer activities in preclinical models and, recently, in cancer patients, highlight...

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Detalles Bibliográficos
Autores principales: Milone, M R, Pucci, B, Bruzzese, F, Carbone, C, Piro, G, Costantini, S, Capone, F, Leone, A, Di Gennaro, E, Caraglia, M, Budillon, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674372/
https://www.ncbi.nlm.nih.gov/pubmed/23703386
http://dx.doi.org/10.1038/cddis.2013.165
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