Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance

Design and efficacy of bioactive drugs is restricted by their (in)ability to traverse cellular membranes. Therapy resistance, a major cause of ineffective cancer treatment, is frequently due to suboptimal intracellular accumulation of the drug. We report a molecular mechanism that promotes trans-mem...

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Detalles Bibliográficos
Autores principales: van Hell, Albert J., Melo, Manuel N., van Blitterswijk, Wim J., Gueth, Dayana M., Braumuller, Tanya M., Pedrosa, Lilia R. C., Song, Ji-Ying, Marrink, Siewert J., Koning, Gerben A., Jonkers, Jos, Verheij, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674426/
https://www.ncbi.nlm.nih.gov/pubmed/23739489
http://dx.doi.org/10.1038/srep01949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674426/
https://www.ncbi.nlm.nih.gov/pubmed/23739489
http://dx.doi.org/10.1038/srep01949

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