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α‐Synuclein: The Long Distance Runner
Parkinson's disease is characterized by α‐synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α‐synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α‐synuclein can transfer fro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674536/ https://www.ncbi.nlm.nih.gov/pubmed/23587141 http://dx.doi.org/10.1111/bpa.12046 |
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author | George, Sonia Rey, Nolwen L. Reichenbach, Nicole Steiner, Jennifer A. Brundin, Patrik |
author_facet | George, Sonia Rey, Nolwen L. Reichenbach, Nicole Steiner, Jennifer A. Brundin, Patrik |
author_sort | George, Sonia |
collection | PubMed |
description | Parkinson's disease is characterized by α‐synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α‐synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α‐synuclein can transfer from cell to cell. In this review, we highlight the involvement of α‐synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion‐like mechanism of α‐synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell‐to‐cell transfer of α‐synuclein and focus our review on the long‐distance axonal transport of α‐synuclein along neurons. |
format | Online Article Text |
id | pubmed-3674536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36745362013-06-06 α‐Synuclein: The Long Distance Runner George, Sonia Rey, Nolwen L. Reichenbach, Nicole Steiner, Jennifer A. Brundin, Patrik Brain Pathol MINI‐SYMPOSIUM: “Prion‐Like” Templated Misfolding in Neurodegenerative Disorders Parkinson's disease is characterized by α‐synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α‐synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α‐synuclein can transfer from cell to cell. In this review, we highlight the involvement of α‐synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion‐like mechanism of α‐synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell‐to‐cell transfer of α‐synuclein and focus our review on the long‐distance axonal transport of α‐synuclein along neurons. John Wiley and Sons Inc. 2013-04-16 /pmc/articles/PMC3674536/ /pubmed/23587141 http://dx.doi.org/10.1111/bpa.12046 Text en © 2013 The Authors; Brain Pathology © 2013 International Society of Neuropathology Open access. |
spellingShingle | MINI‐SYMPOSIUM: “Prion‐Like” Templated Misfolding in Neurodegenerative Disorders George, Sonia Rey, Nolwen L. Reichenbach, Nicole Steiner, Jennifer A. Brundin, Patrik α‐Synuclein: The Long Distance Runner |
title | α‐Synuclein: The Long Distance Runner |
title_full | α‐Synuclein: The Long Distance Runner |
title_fullStr | α‐Synuclein: The Long Distance Runner |
title_full_unstemmed | α‐Synuclein: The Long Distance Runner |
title_short | α‐Synuclein: The Long Distance Runner |
title_sort | α‐synuclein: the long distance runner |
topic | MINI‐SYMPOSIUM: “Prion‐Like” Templated Misfolding in Neurodegenerative Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674536/ https://www.ncbi.nlm.nih.gov/pubmed/23587141 http://dx.doi.org/10.1111/bpa.12046 |
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