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Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus

INTRODUCTION: Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selecti...

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Detalles Bibliográficos
Autores principales:	Hutcheson, Jack, Vanarsa, Kamala, Bashmakov, Anna, Grewal, Simer, Sajitharan, Deena, Chang, Betty Y, Buggy, Joseph J, Zhou, Xin J, Du, Yong, Satterthwaite, Anne B, Mohan, Chandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674619/ https://www.ncbi.nlm.nih.gov/pubmed/23136880 http://dx.doi.org/10.1186/ar4086

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