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Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes

INTRODUCTION: Extracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory cytokine interleukin-1 beta (IL-1β) functions in ECM degradation and prevents ECM synthesis by down-regulating the key transcription factor, Sox9, and consequently inhibiti...

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Detalles Bibliográficos
Autores principales:	Dai, Linghui, Zhang, Xin, Hu, Xiaoqing, Zhou, Chunyan, Ao, Yingfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674628/ https://www.ncbi.nlm.nih.gov/pubmed/23227940 http://dx.doi.org/10.1186/ar4114

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