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Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

INTRODUCTION: Progranulin (PGRN) is the precursor of granulin (GRN), a soluble cofactor for toll-like receptor 9 (TLR9) signaling evoked by oligonucleotide (CpG)-DNA. Because TLR9 signaling plays an important role in systemic lupus erythematosus (SLE), we investigated whether PGRN is involved in the...

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Detalles Bibliográficos
Autores principales:	Tanaka, Atsushi, Tsukamoto, Hiroshi, Mitoma, Hiroki, Kiyohara, Chikako, Ueda, Naoyasu, Ayano, Masahiro, Ohta, Shun-ichiro, Inoue, Yasushi, Arinobu, Yojirou, Niiro, Hiroaki, Horiuchi, Takahiko, Akashi, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674629/ https://www.ncbi.nlm.nih.gov/pubmed/23140401 http://dx.doi.org/10.1186/ar4087

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