Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice

INTRODUCTION: Naturally occurring CD4(+)CD25(+ )regulatory T (Treg) cells are central to the maintenance of peripheral tolerance. Impaired activity and/or a lower frequency of these cells lead to systemic lupus erythematosus (SLE). Manipulating the number or activity of Treg cells is to be a promisi...

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Detalles Bibliográficos
Autores principales: Xiao, Zhi-Yong, Chen, Shao-Hui, Cheng, Jun-Ping, Zhou, Wen-Xia, Zhang, Yong-Xiang, Yang, Ri-Fang, Yun, Liu-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674632/
https://www.ncbi.nlm.nih.gov/pubmed/23116248
http://dx.doi.org/10.1186/ar4078

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