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Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction
Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause ser...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674739/ https://www.ncbi.nlm.nih.gov/pubmed/23762054 http://dx.doi.org/10.1155/2013/828532 |
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author | Gregoraszczuk, Ewa L. Ptak, Anna |
author_facet | Gregoraszczuk, Ewa L. Ptak, Anna |
author_sort | Gregoraszczuk, Ewa L. |
collection | PubMed |
description | Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause serious reproductive problems, including ovotoxic action, lack of ovulation, premature ovarian failure (POF), or polycystic ovarian syndrome (PCOS). Most of the representatives of POPs influence the activation of transcription factors, not only activation of aromatic hydrocarbon receptor (AhR), but also the steroid hormone receptors. This minireview will focus on a variety of PAH activities in oocyte, ovary, placenta, and mammary gland. The complexity and diversity of factors belonging to POPs and disorders of the reproductive function of women indicate that the impact of environmental pollution as an important determinant factor in fertility should not be minimize. |
format | Online Article Text |
id | pubmed-3674739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36747392013-06-12 Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction Gregoraszczuk, Ewa L. Ptak, Anna Int J Endocrinol Review Article Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause serious reproductive problems, including ovotoxic action, lack of ovulation, premature ovarian failure (POF), or polycystic ovarian syndrome (PCOS). Most of the representatives of POPs influence the activation of transcription factors, not only activation of aromatic hydrocarbon receptor (AhR), but also the steroid hormone receptors. This minireview will focus on a variety of PAH activities in oocyte, ovary, placenta, and mammary gland. The complexity and diversity of factors belonging to POPs and disorders of the reproductive function of women indicate that the impact of environmental pollution as an important determinant factor in fertility should not be minimize. Hindawi Publishing Corporation 2013 2013-05-23 /pmc/articles/PMC3674739/ /pubmed/23762054 http://dx.doi.org/10.1155/2013/828532 Text en Copyright © 2013 E. L. Gregoraszczuk and A. Ptak. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gregoraszczuk, Ewa L. Ptak, Anna Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction |
title | Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction |
title_full | Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction |
title_fullStr | Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction |
title_full_unstemmed | Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction |
title_short | Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction |
title_sort | endocrine-disrupting chemicals: some actions of pops on female reproduction |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674739/ https://www.ncbi.nlm.nih.gov/pubmed/23762054 http://dx.doi.org/10.1155/2013/828532 |
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