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Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing
Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease. Aberrant alternative splicing of exon 10 in the tau pre-mRNA resulting in an imbalance of tau isoforms is one of the molecular causes of the inherited tauopathy, FTDP-1...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674800/ https://www.ncbi.nlm.nih.gov/pubmed/23459933 http://dx.doi.org/10.1093/hmg/ddt108 |