ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules

Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing. Large FUS-immunoreactive inclusions fill the perikaryon of surviving mo...

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Detalles Bibliográficos
Autores principales: Vance, Caroline, Scotter, Emma L., Nishimura, Agnes L., Troakes, Claire, Mitchell, Jacqueline C., Kathe, Claudia, Urwin, Hazel, Manser, Catherine, Miller, Christopher C., Hortobágyi, Tibor, Dragunow, Mike, Rogelj, Boris, Shaw, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674807/
https://www.ncbi.nlm.nih.gov/pubmed/23474818
http://dx.doi.org/10.1093/hmg/ddt117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674807/
https://www.ncbi.nlm.nih.gov/pubmed/23474818
http://dx.doi.org/10.1093/hmg/ddt117

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