The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only...

Descripción completa

Detalles Bibliográficos
Autores principales: van Dam, Teunis JP, Wheway, Gabrielle, Slaats, Gisela G, Huynen, Martijn A, Giles, Rachel H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674929/
https://www.ncbi.nlm.nih.gov/pubmed/23725226
http://dx.doi.org/10.1186/2046-2530-2-7
_version_ 1782272433654333440
author van Dam, Teunis JP
Wheway, Gabrielle
Slaats, Gisela G
Huynen, Martijn A
Giles, Rachel H
author_facet van Dam, Teunis JP
Wheway, Gabrielle
Slaats, Gisela G
Huynen, Martijn A
Giles, Rachel H
author_sort van Dam, Teunis JP
collection PubMed
description The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource.
format Online
Article
Text
id pubmed-3674929
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36749292013-06-10 The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium van Dam, Teunis JP Wheway, Gabrielle Slaats, Gisela G Huynen, Martijn A Giles, Rachel H Cilia Review The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variable phenotypes of ciliopathies. The models generated are only as good as the wet laboratory data fed into them. It is therefore essential to orchestrate a well-annotated and high-confidence dataset to be able to assess the quality of any HTP dataset. Here, we present the inaugural SYSCILIA gold standard of known ciliary components as a public resource. BioMed Central 2013-05-31 /pmc/articles/PMC3674929/ /pubmed/23725226 http://dx.doi.org/10.1186/2046-2530-2-7 Text en Copyright © 2013 van Dam et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
van Dam, Teunis JP
Wheway, Gabrielle
Slaats, Gisela G
Huynen, Martijn A
Giles, Rachel H
The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
title The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
title_full The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
title_fullStr The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
title_full_unstemmed The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
title_short The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium
title_sort syscilia gold standard (scgsv1) of known ciliary components and its applications within a systems biology consortium
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674929/
https://www.ncbi.nlm.nih.gov/pubmed/23725226
http://dx.doi.org/10.1186/2046-2530-2-7
work_keys_str_mv AT vandamteunisjp thesysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT whewaygabrielle thesysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT slaatsgiselag thesysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT huynenmartijna thesysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT gilesrachelh thesysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT vandamteunisjp sysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT whewaygabrielle sysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT slaatsgiselag sysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT huynenmartijna sysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium
AT gilesrachelh sysciliagoldstandardscgsv1ofknownciliarycomponentsanditsapplicationswithinasystemsbiologyconsortium

Ejemplares similares