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Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors

Currently, cryopreservation of oocytes, embryos and ovarian tissue is considered the basis of fertility preservation programs for women with cancer and other diseases who are rendered sterile by gonadotoxic drugs or radiation. Numerous studies have confirmed that autograft of frozen-thawed ovarian t...

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Autores principales: Callejo, Justo, Salvador, Cristina, González-Nuñez, Santiago, Almeida, Laura, Rodriguez, Luciano, Marqués, Laura, Valls, Ana, Lailla, José Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674930/
https://www.ncbi.nlm.nih.gov/pubmed/23647552
http://dx.doi.org/10.1186/1757-2215-6-33
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author Callejo, Justo
Salvador, Cristina
González-Nuñez, Santiago
Almeida, Laura
Rodriguez, Luciano
Marqués, Laura
Valls, Ana
Lailla, José Maria
author_facet Callejo, Justo
Salvador, Cristina
González-Nuñez, Santiago
Almeida, Laura
Rodriguez, Luciano
Marqués, Laura
Valls, Ana
Lailla, José Maria
author_sort Callejo, Justo
collection PubMed
description Currently, cryopreservation of oocytes, embryos and ovarian tissue is considered the basis of fertility preservation programs for women with cancer and other diseases who are rendered sterile by gonadotoxic drugs or radiation. Numerous studies have confirmed that autograft of frozen-thawed ovarian tissue can restore ovarian function and fertility. A total of twenty-two live births have been reported but we still have to consider this technique as experimental. The main problem is that the implant undergoes ischemia until neoangiogenesis is restored, resulting in significant follicular loss. At the moment, there are numerous publications in different medical fields that publish successful experiences with plasma rich in platelets (PRP) in different clinical situations promoting angiogenesis. Thus, we considered the possibility of using it in the field of ovarian autologous transplantation in order to improve the vascularization of the implant and its quality. For this, both thawed ovarian tissue as practiced pockets on the rear side of the broad ligament which have been placed, have been impregnated with PRP. We can say that the implant treated in this way has had a rapid and successful response. We report a special interesting case because this is the first time that this technique is performed successfully in a woman without ovaries combined with growth factors to promote neoangiogenesis. Obviously, the results of the hormonal response come exclusively from the implanted tissue in these special conditions.
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spelling pubmed-36749302013-06-07 Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors Callejo, Justo Salvador, Cristina González-Nuñez, Santiago Almeida, Laura Rodriguez, Luciano Marqués, Laura Valls, Ana Lailla, José Maria J Ovarian Res Case Report Currently, cryopreservation of oocytes, embryos and ovarian tissue is considered the basis of fertility preservation programs for women with cancer and other diseases who are rendered sterile by gonadotoxic drugs or radiation. Numerous studies have confirmed that autograft of frozen-thawed ovarian tissue can restore ovarian function and fertility. A total of twenty-two live births have been reported but we still have to consider this technique as experimental. The main problem is that the implant undergoes ischemia until neoangiogenesis is restored, resulting in significant follicular loss. At the moment, there are numerous publications in different medical fields that publish successful experiences with plasma rich in platelets (PRP) in different clinical situations promoting angiogenesis. Thus, we considered the possibility of using it in the field of ovarian autologous transplantation in order to improve the vascularization of the implant and its quality. For this, both thawed ovarian tissue as practiced pockets on the rear side of the broad ligament which have been placed, have been impregnated with PRP. We can say that the implant treated in this way has had a rapid and successful response. We report a special interesting case because this is the first time that this technique is performed successfully in a woman without ovaries combined with growth factors to promote neoangiogenesis. Obviously, the results of the hormonal response come exclusively from the implanted tissue in these special conditions. BioMed Central 2013-05-07 /pmc/articles/PMC3674930/ /pubmed/23647552 http://dx.doi.org/10.1186/1757-2215-6-33 Text en Copyright © 2013 Callejo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Callejo, Justo
Salvador, Cristina
González-Nuñez, Santiago
Almeida, Laura
Rodriguez, Luciano
Marqués, Laura
Valls, Ana
Lailla, José Maria
Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
title Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
title_full Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
title_fullStr Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
title_full_unstemmed Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
title_short Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
title_sort live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674930/
https://www.ncbi.nlm.nih.gov/pubmed/23647552
http://dx.doi.org/10.1186/1757-2215-6-33
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