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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 i...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674993/ https://www.ncbi.nlm.nih.gov/pubmed/23754948 http://dx.doi.org/10.1371/journal.pgen.1003500 |
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| author | Randall, Joshua C. Winkler, Thomas W. Kutalik, Zoltán Berndt, Sonja I. Jackson, Anne U. Monda, Keri L. Kilpeläinen, Tuomas O. Esko, Tõnu Mägi, Reedik Li, Shengxu Workalemahu, Tsegaselassie Feitosa, Mary F. Croteau-Chonka, Damien C. Day, Felix R. Fall, Tove Ferreira, Teresa Gustafsson, Stefan Locke, Adam E. Mathieson, Iain Scherag, Andre Vedantam, Sailaja Wood, Andrew R. Liang, Liming Steinthorsdottir, Valgerdur Thorleifsson, Gudmar Dermitzakis, Emmanouil T. Dimas, Antigone S. Karpe, Fredrik Min, Josine L. Nicholson, George Clegg, Deborah J. Person, Thomas Krohn, Jon P. Bauer, Sabrina Buechler, Christa Eisinger, Kristina Bonnefond, Amélie Froguel, Philippe Hottenga, Jouke-Jan Prokopenko, Inga Waite, Lindsay L. Harris, Tamara B. Smith, Albert Vernon Shuldiner, Alan R. McArdle, Wendy L. Caulfield, Mark J. Munroe, Patricia B. Grönberg, Henrik Chen, Yii-Der Ida Li, Guo Beckmann, Jacques S. Johnson, Toby Thorsteinsdottir, Unnur Teder-Laving, Maris Khaw, Kay-Tee Wareham, Nicholas J. Zhao, Jing Hua Amin, Najaf Oostra, Ben A. Kraja, Aldi T. Province, Michael A. Cupples, L. Adrienne Heard-Costa, Nancy L. Kaprio, Jaakko Ripatti, Samuli Surakka, Ida Collins, Francis S. Saramies, Jouko Tuomilehto, Jaakko Jula, Antti Salomaa, Veikko Erdmann, Jeanette Hengstenberg, Christian Loley, Christina Schunkert, Heribert Lamina, Claudia Wichmann, H. Erich Albrecht, Eva Gieger, Christian Hicks, Andrew A. Johansson, Åsa Pramstaller, Peter P. Kathiresan, Sekar Speliotes, Elizabeth K. Penninx, Brenda Hartikainen, Anna-Liisa Jarvelin, Marjo-Riitta Gyllensten, Ulf Boomsma, Dorret I. Campbell, Harry Wilson, James F. Chanock, Stephen J. Farrall, Martin Goel, Anuj Medina-Gomez, Carolina Rivadeneira, Fernando Estrada, Karol Uitterlinden, André G. Hofman, Albert Zillikens, M. Carola den Heijer, Martin Kiemeney, Lambertus A. Maschio, Andrea Hall, Per Tyrer, Jonathan Teumer, Alexander Völzke, Henry Kovacs, Peter Tönjes, Anke Mangino, Massimo Spector, Tim D. Hayward, Caroline Rudan, Igor Hall, Alistair S. Samani, Nilesh J. Attwood, Antony Paul Sambrook, Jennifer G. Hung, Joseph Palmer, Lyle J. Lokki, Marja-Liisa Sinisalo, Juha Boucher, Gabrielle Huikuri, Heikki Lorentzon, Mattias Ohlsson, Claes Eklund, Niina Eriksson, Johan G. Barlassina, Cristina Rivolta, Carlo Nolte, Ilja M. Snieder, Harold Van der Klauw, Melanie M. Van Vliet-Ostaptchouk, Jana V. Gejman, Pablo V. Shi, Jianxin Jacobs, Kevin B. Wang, Zhaoming Bakker, Stephan J. L. Mateo Leach, Irene Navis, Gerjan van der Harst, Pim Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Yang, Jian Chasman, Daniel I. Ridker, Paul M. Rose, Lynda M. Lehtimäki, Terho Raitakari, Olli Absher, Devin Iribarren, Carlos Basart, Hanneke Hovingh, Kees G. Hyppönen, Elina Power, Chris Anderson, Denise Beilby, John P. Hui, Jennie Jolley, Jennifer Sager, Hendrik Bornstein, Stefan R. Schwarz, Peter E. H. Kristiansson, Kati Perola, Markus Lindström, Jaana Swift, Amy J. Uusitupa, Matti Atalay, Mustafa Lakka, Timo A. Rauramaa, Rainer Bolton, Jennifer L. Fowkes, Gerry Fraser, Ross M. Price, Jackie F. Fischer, Krista KrjutÅ¡kov, Kaarel Metspalu, Andres Mihailov, Evelin Langenberg, Claudia Luan, Jian'an Ong, Ken K. Chines, Peter S. Keinanen-Kiukaanniemi, Sirkka M. Saaristo, Timo E. Edkins, Sarah Franks, Paul W. Hallmans, Göran Shungin, Dmitry Morris, Andrew David Palmer, Colin N. A. Erbel, Raimund Moebus, Susanne Nöthen, Markus M. Pechlivanis, Sonali Hveem, Kristian Narisu, Narisu Hamsten, Anders Humphries, Steve E. Strawbridge, Rona J. Tremoli, Elena Grallert, Harald Thorand, Barbara Illig, Thomas Koenig, Wolfgang Müller-Nurasyid, Martina Peters, Annette Boehm, Bernhard O. Kleber, Marcus E. März, Winfried Winkelmann, Bernhard R. Kuusisto, Johanna Laakso, Markku Arveiler, Dominique Cesana, Giancarlo Kuulasmaa, Kari Virtamo, Jarmo Yarnell, John W. G. Kuh, Diana Wong, Andrew Lind, Lars de Faire, Ulf Gigante, Bruna Magnusson, Patrik K. E. Pedersen, Nancy L. Dedoussis, George Dimitriou, Maria Kolovou, Genovefa Kanoni, Stavroula Stirrups, Kathleen Bonnycastle, Lori L. Njølstad, Inger Wilsgaard, Tom Ganna, Andrea Rehnberg, Emil Hingorani, Aroon Kivimaki, Mika Kumari, Meena Assimes, Themistocles L. Barroso, Inês Boehnke, Michael Borecki, Ingrid B. Deloukas, Panos Fox, Caroline S. Frayling, Timothy Groop, Leif C. Haritunians, Talin Hunter, David Ingelsson, Erik Kaplan, Robert Mohlke, Karen L. O'Connell, Jeffrey R. Schlessinger, David Strachan, David P. Stefansson, Kari van Duijn, Cornelia M. Abecasis, Gonçalo R. McCarthy, Mark I. Hirschhorn, Joel N. Qi, Lu Loos, Ruth J. F. Lindgren, Cecilia M. North, Kari E. Heid, Iris M. |
| author_facet | Randall, Joshua C. Winkler, Thomas W. Kutalik, Zoltán Berndt, Sonja I. Jackson, Anne U. Monda, Keri L. Kilpeläinen, Tuomas O. Esko, Tõnu Mägi, Reedik Li, Shengxu Workalemahu, Tsegaselassie Feitosa, Mary F. Croteau-Chonka, Damien C. Day, Felix R. Fall, Tove Ferreira, Teresa Gustafsson, Stefan Locke, Adam E. Mathieson, Iain Scherag, Andre Vedantam, Sailaja Wood, Andrew R. Liang, Liming Steinthorsdottir, Valgerdur Thorleifsson, Gudmar Dermitzakis, Emmanouil T. Dimas, Antigone S. Karpe, Fredrik Min, Josine L. Nicholson, George Clegg, Deborah J. Person, Thomas Krohn, Jon P. Bauer, Sabrina Buechler, Christa Eisinger, Kristina Bonnefond, Amélie Froguel, Philippe Hottenga, Jouke-Jan Prokopenko, Inga Waite, Lindsay L. Harris, Tamara B. Smith, Albert Vernon Shuldiner, Alan R. McArdle, Wendy L. Caulfield, Mark J. Munroe, Patricia B. Grönberg, Henrik Chen, Yii-Der Ida Li, Guo Beckmann, Jacques S. Johnson, Toby Thorsteinsdottir, Unnur Teder-Laving, Maris Khaw, Kay-Tee Wareham, Nicholas J. Zhao, Jing Hua Amin, Najaf Oostra, Ben A. Kraja, Aldi T. Province, Michael A. Cupples, L. Adrienne Heard-Costa, Nancy L. Kaprio, Jaakko Ripatti, Samuli Surakka, Ida Collins, Francis S. Saramies, Jouko Tuomilehto, Jaakko Jula, Antti Salomaa, Veikko Erdmann, Jeanette Hengstenberg, Christian Loley, Christina Schunkert, Heribert Lamina, Claudia Wichmann, H. Erich Albrecht, Eva Gieger, Christian Hicks, Andrew A. Johansson, Åsa Pramstaller, Peter P. Kathiresan, Sekar Speliotes, Elizabeth K. Penninx, Brenda Hartikainen, Anna-Liisa Jarvelin, Marjo-Riitta Gyllensten, Ulf Boomsma, Dorret I. Campbell, Harry Wilson, James F. Chanock, Stephen J. Farrall, Martin Goel, Anuj Medina-Gomez, Carolina Rivadeneira, Fernando Estrada, Karol Uitterlinden, André G. Hofman, Albert Zillikens, M. Carola den Heijer, Martin Kiemeney, Lambertus A. Maschio, Andrea Hall, Per Tyrer, Jonathan Teumer, Alexander Völzke, Henry Kovacs, Peter Tönjes, Anke Mangino, Massimo Spector, Tim D. Hayward, Caroline Rudan, Igor Hall, Alistair S. Samani, Nilesh J. Attwood, Antony Paul Sambrook, Jennifer G. Hung, Joseph Palmer, Lyle J. Lokki, Marja-Liisa Sinisalo, Juha Boucher, Gabrielle Huikuri, Heikki Lorentzon, Mattias Ohlsson, Claes Eklund, Niina Eriksson, Johan G. Barlassina, Cristina Rivolta, Carlo Nolte, Ilja M. Snieder, Harold Van der Klauw, Melanie M. Van Vliet-Ostaptchouk, Jana V. Gejman, Pablo V. Shi, Jianxin Jacobs, Kevin B. Wang, Zhaoming Bakker, Stephan J. L. Mateo Leach, Irene Navis, Gerjan van der Harst, Pim Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Yang, Jian Chasman, Daniel I. Ridker, Paul M. Rose, Lynda M. Lehtimäki, Terho Raitakari, Olli Absher, Devin Iribarren, Carlos Basart, Hanneke Hovingh, Kees G. Hyppönen, Elina Power, Chris Anderson, Denise Beilby, John P. Hui, Jennie Jolley, Jennifer Sager, Hendrik Bornstein, Stefan R. Schwarz, Peter E. H. Kristiansson, Kati Perola, Markus Lindström, Jaana Swift, Amy J. Uusitupa, Matti Atalay, Mustafa Lakka, Timo A. Rauramaa, Rainer Bolton, Jennifer L. Fowkes, Gerry Fraser, Ross M. Price, Jackie F. Fischer, Krista KrjutÅ¡kov, Kaarel Metspalu, Andres Mihailov, Evelin Langenberg, Claudia Luan, Jian'an Ong, Ken K. Chines, Peter S. Keinanen-Kiukaanniemi, Sirkka M. Saaristo, Timo E. Edkins, Sarah Franks, Paul W. Hallmans, Göran Shungin, Dmitry Morris, Andrew David Palmer, Colin N. A. Erbel, Raimund Moebus, Susanne Nöthen, Markus M. Pechlivanis, Sonali Hveem, Kristian Narisu, Narisu Hamsten, Anders Humphries, Steve E. Strawbridge, Rona J. Tremoli, Elena Grallert, Harald Thorand, Barbara Illig, Thomas Koenig, Wolfgang Müller-Nurasyid, Martina Peters, Annette Boehm, Bernhard O. Kleber, Marcus E. März, Winfried Winkelmann, Bernhard R. Kuusisto, Johanna Laakso, Markku Arveiler, Dominique Cesana, Giancarlo Kuulasmaa, Kari Virtamo, Jarmo Yarnell, John W. G. Kuh, Diana Wong, Andrew Lind, Lars de Faire, Ulf Gigante, Bruna Magnusson, Patrik K. E. Pedersen, Nancy L. Dedoussis, George Dimitriou, Maria Kolovou, Genovefa Kanoni, Stavroula Stirrups, Kathleen Bonnycastle, Lori L. Njølstad, Inger Wilsgaard, Tom Ganna, Andrea Rehnberg, Emil Hingorani, Aroon Kivimaki, Mika Kumari, Meena Assimes, Themistocles L. Barroso, Inês Boehnke, Michael Borecki, Ingrid B. Deloukas, Panos Fox, Caroline S. Frayling, Timothy Groop, Leif C. Haritunians, Talin Hunter, David Ingelsson, Erik Kaplan, Robert Mohlke, Karen L. O'Connell, Jeffrey R. Schlessinger, David Strachan, David P. Stefansson, Kari van Duijn, Cornelia M. Abecasis, Gonçalo R. McCarthy, Mark I. Hirschhorn, Joel N. Qi, Lu Loos, Ruth J. F. Lindgren, Cecilia M. North, Kari E. Heid, Iris M. |
| author_sort | Randall, Joshua C. |
| collection | PubMed |
| description | Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10(−8)), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits. |
| format | Online Article Text |
| id | pubmed-3674993 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36749932013-06-10 Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits Randall, Joshua C. Winkler, Thomas W. Kutalik, Zoltán Berndt, Sonja I. Jackson, Anne U. Monda, Keri L. Kilpeläinen, Tuomas O. Esko, Tõnu Mägi, Reedik Li, Shengxu Workalemahu, Tsegaselassie Feitosa, Mary F. Croteau-Chonka, Damien C. Day, Felix R. Fall, Tove Ferreira, Teresa Gustafsson, Stefan Locke, Adam E. Mathieson, Iain Scherag, Andre Vedantam, Sailaja Wood, Andrew R. Liang, Liming Steinthorsdottir, Valgerdur Thorleifsson, Gudmar Dermitzakis, Emmanouil T. Dimas, Antigone S. Karpe, Fredrik Min, Josine L. Nicholson, George Clegg, Deborah J. Person, Thomas Krohn, Jon P. Bauer, Sabrina Buechler, Christa Eisinger, Kristina Bonnefond, Amélie Froguel, Philippe Hottenga, Jouke-Jan Prokopenko, Inga Waite, Lindsay L. Harris, Tamara B. Smith, Albert Vernon Shuldiner, Alan R. McArdle, Wendy L. Caulfield, Mark J. Munroe, Patricia B. Grönberg, Henrik Chen, Yii-Der Ida Li, Guo Beckmann, Jacques S. Johnson, Toby Thorsteinsdottir, Unnur Teder-Laving, Maris Khaw, Kay-Tee Wareham, Nicholas J. Zhao, Jing Hua Amin, Najaf Oostra, Ben A. Kraja, Aldi T. Province, Michael A. Cupples, L. Adrienne Heard-Costa, Nancy L. Kaprio, Jaakko Ripatti, Samuli Surakka, Ida Collins, Francis S. Saramies, Jouko Tuomilehto, Jaakko Jula, Antti Salomaa, Veikko Erdmann, Jeanette Hengstenberg, Christian Loley, Christina Schunkert, Heribert Lamina, Claudia Wichmann, H. Erich Albrecht, Eva Gieger, Christian Hicks, Andrew A. Johansson, Åsa Pramstaller, Peter P. Kathiresan, Sekar Speliotes, Elizabeth K. Penninx, Brenda Hartikainen, Anna-Liisa Jarvelin, Marjo-Riitta Gyllensten, Ulf Boomsma, Dorret I. Campbell, Harry Wilson, James F. Chanock, Stephen J. Farrall, Martin Goel, Anuj Medina-Gomez, Carolina Rivadeneira, Fernando Estrada, Karol Uitterlinden, André G. Hofman, Albert Zillikens, M. Carola den Heijer, Martin Kiemeney, Lambertus A. Maschio, Andrea Hall, Per Tyrer, Jonathan Teumer, Alexander Völzke, Henry Kovacs, Peter Tönjes, Anke Mangino, Massimo Spector, Tim D. Hayward, Caroline Rudan, Igor Hall, Alistair S. Samani, Nilesh J. Attwood, Antony Paul Sambrook, Jennifer G. Hung, Joseph Palmer, Lyle J. Lokki, Marja-Liisa Sinisalo, Juha Boucher, Gabrielle Huikuri, Heikki Lorentzon, Mattias Ohlsson, Claes Eklund, Niina Eriksson, Johan G. Barlassina, Cristina Rivolta, Carlo Nolte, Ilja M. Snieder, Harold Van der Klauw, Melanie M. Van Vliet-Ostaptchouk, Jana V. Gejman, Pablo V. Shi, Jianxin Jacobs, Kevin B. Wang, Zhaoming Bakker, Stephan J. L. Mateo Leach, Irene Navis, Gerjan van der Harst, Pim Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Yang, Jian Chasman, Daniel I. Ridker, Paul M. Rose, Lynda M. Lehtimäki, Terho Raitakari, Olli Absher, Devin Iribarren, Carlos Basart, Hanneke Hovingh, Kees G. Hyppönen, Elina Power, Chris Anderson, Denise Beilby, John P. Hui, Jennie Jolley, Jennifer Sager, Hendrik Bornstein, Stefan R. Schwarz, Peter E. H. Kristiansson, Kati Perola, Markus Lindström, Jaana Swift, Amy J. Uusitupa, Matti Atalay, Mustafa Lakka, Timo A. Rauramaa, Rainer Bolton, Jennifer L. Fowkes, Gerry Fraser, Ross M. Price, Jackie F. Fischer, Krista KrjutÅ¡kov, Kaarel Metspalu, Andres Mihailov, Evelin Langenberg, Claudia Luan, Jian'an Ong, Ken K. Chines, Peter S. Keinanen-Kiukaanniemi, Sirkka M. Saaristo, Timo E. Edkins, Sarah Franks, Paul W. Hallmans, Göran Shungin, Dmitry Morris, Andrew David Palmer, Colin N. A. Erbel, Raimund Moebus, Susanne Nöthen, Markus M. Pechlivanis, Sonali Hveem, Kristian Narisu, Narisu Hamsten, Anders Humphries, Steve E. Strawbridge, Rona J. Tremoli, Elena Grallert, Harald Thorand, Barbara Illig, Thomas Koenig, Wolfgang Müller-Nurasyid, Martina Peters, Annette Boehm, Bernhard O. Kleber, Marcus E. März, Winfried Winkelmann, Bernhard R. Kuusisto, Johanna Laakso, Markku Arveiler, Dominique Cesana, Giancarlo Kuulasmaa, Kari Virtamo, Jarmo Yarnell, John W. G. Kuh, Diana Wong, Andrew Lind, Lars de Faire, Ulf Gigante, Bruna Magnusson, Patrik K. E. Pedersen, Nancy L. Dedoussis, George Dimitriou, Maria Kolovou, Genovefa Kanoni, Stavroula Stirrups, Kathleen Bonnycastle, Lori L. Njølstad, Inger Wilsgaard, Tom Ganna, Andrea Rehnberg, Emil Hingorani, Aroon Kivimaki, Mika Kumari, Meena Assimes, Themistocles L. Barroso, Inês Boehnke, Michael Borecki, Ingrid B. Deloukas, Panos Fox, Caroline S. Frayling, Timothy Groop, Leif C. Haritunians, Talin Hunter, David Ingelsson, Erik Kaplan, Robert Mohlke, Karen L. O'Connell, Jeffrey R. Schlessinger, David Strachan, David P. Stefansson, Kari van Duijn, Cornelia M. Abecasis, Gonçalo R. McCarthy, Mark I. Hirschhorn, Joel N. Qi, Lu Loos, Ruth J. F. Lindgren, Cecilia M. North, Kari E. Heid, Iris M. PLoS Genet Research Article Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5×10(−8)), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits. Public Library of Science 2013-06-06 /pmc/articles/PMC3674993/ /pubmed/23754948 http://dx.doi.org/10.1371/journal.pgen.1003500 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| spellingShingle | Research Article Randall, Joshua C. Winkler, Thomas W. Kutalik, Zoltán Berndt, Sonja I. Jackson, Anne U. Monda, Keri L. Kilpeläinen, Tuomas O. Esko, Tõnu Mägi, Reedik Li, Shengxu Workalemahu, Tsegaselassie Feitosa, Mary F. Croteau-Chonka, Damien C. Day, Felix R. Fall, Tove Ferreira, Teresa Gustafsson, Stefan Locke, Adam E. Mathieson, Iain Scherag, Andre Vedantam, Sailaja Wood, Andrew R. Liang, Liming Steinthorsdottir, Valgerdur Thorleifsson, Gudmar Dermitzakis, Emmanouil T. Dimas, Antigone S. Karpe, Fredrik Min, Josine L. Nicholson, George Clegg, Deborah J. Person, Thomas Krohn, Jon P. Bauer, Sabrina Buechler, Christa Eisinger, Kristina Bonnefond, Amélie Froguel, Philippe Hottenga, Jouke-Jan Prokopenko, Inga Waite, Lindsay L. Harris, Tamara B. Smith, Albert Vernon Shuldiner, Alan R. McArdle, Wendy L. Caulfield, Mark J. Munroe, Patricia B. Grönberg, Henrik Chen, Yii-Der Ida Li, Guo Beckmann, Jacques S. Johnson, Toby Thorsteinsdottir, Unnur Teder-Laving, Maris Khaw, Kay-Tee Wareham, Nicholas J. Zhao, Jing Hua Amin, Najaf Oostra, Ben A. Kraja, Aldi T. Province, Michael A. Cupples, L. Adrienne Heard-Costa, Nancy L. Kaprio, Jaakko Ripatti, Samuli Surakka, Ida Collins, Francis S. Saramies, Jouko Tuomilehto, Jaakko Jula, Antti Salomaa, Veikko Erdmann, Jeanette Hengstenberg, Christian Loley, Christina Schunkert, Heribert Lamina, Claudia Wichmann, H. Erich Albrecht, Eva Gieger, Christian Hicks, Andrew A. Johansson, Åsa Pramstaller, Peter P. Kathiresan, Sekar Speliotes, Elizabeth K. Penninx, Brenda Hartikainen, Anna-Liisa Jarvelin, Marjo-Riitta Gyllensten, Ulf Boomsma, Dorret I. Campbell, Harry Wilson, James F. Chanock, Stephen J. Farrall, Martin Goel, Anuj Medina-Gomez, Carolina Rivadeneira, Fernando Estrada, Karol Uitterlinden, André G. Hofman, Albert Zillikens, M. Carola den Heijer, Martin Kiemeney, Lambertus A. Maschio, Andrea Hall, Per Tyrer, Jonathan Teumer, Alexander Völzke, Henry Kovacs, Peter Tönjes, Anke Mangino, Massimo Spector, Tim D. Hayward, Caroline Rudan, Igor Hall, Alistair S. Samani, Nilesh J. Attwood, Antony Paul Sambrook, Jennifer G. Hung, Joseph Palmer, Lyle J. Lokki, Marja-Liisa Sinisalo, Juha Boucher, Gabrielle Huikuri, Heikki Lorentzon, Mattias Ohlsson, Claes Eklund, Niina Eriksson, Johan G. Barlassina, Cristina Rivolta, Carlo Nolte, Ilja M. Snieder, Harold Van der Klauw, Melanie M. Van Vliet-Ostaptchouk, Jana V. Gejman, Pablo V. Shi, Jianxin Jacobs, Kevin B. Wang, Zhaoming Bakker, Stephan J. L. Mateo Leach, Irene Navis, Gerjan van der Harst, Pim Martin, Nicholas G. Medland, Sarah E. Montgomery, Grant W. Yang, Jian Chasman, Daniel I. Ridker, Paul M. Rose, Lynda M. Lehtimäki, Terho Raitakari, Olli Absher, Devin Iribarren, Carlos Basart, Hanneke Hovingh, Kees G. Hyppönen, Elina Power, Chris Anderson, Denise Beilby, John P. Hui, Jennie Jolley, Jennifer Sager, Hendrik Bornstein, Stefan R. Schwarz, Peter E. H. Kristiansson, Kati Perola, Markus Lindström, Jaana Swift, Amy J. Uusitupa, Matti Atalay, Mustafa Lakka, Timo A. Rauramaa, Rainer Bolton, Jennifer L. Fowkes, Gerry Fraser, Ross M. Price, Jackie F. Fischer, Krista KrjutÅ¡kov, Kaarel Metspalu, Andres Mihailov, Evelin Langenberg, Claudia Luan, Jian'an Ong, Ken K. Chines, Peter S. Keinanen-Kiukaanniemi, Sirkka M. Saaristo, Timo E. Edkins, Sarah Franks, Paul W. Hallmans, Göran Shungin, Dmitry Morris, Andrew David Palmer, Colin N. A. Erbel, Raimund Moebus, Susanne Nöthen, Markus M. Pechlivanis, Sonali Hveem, Kristian Narisu, Narisu Hamsten, Anders Humphries, Steve E. Strawbridge, Rona J. Tremoli, Elena Grallert, Harald Thorand, Barbara Illig, Thomas Koenig, Wolfgang Müller-Nurasyid, Martina Peters, Annette Boehm, Bernhard O. Kleber, Marcus E. März, Winfried Winkelmann, Bernhard R. Kuusisto, Johanna Laakso, Markku Arveiler, Dominique Cesana, Giancarlo Kuulasmaa, Kari Virtamo, Jarmo Yarnell, John W. G. Kuh, Diana Wong, Andrew Lind, Lars de Faire, Ulf Gigante, Bruna Magnusson, Patrik K. E. Pedersen, Nancy L. Dedoussis, George Dimitriou, Maria Kolovou, Genovefa Kanoni, Stavroula Stirrups, Kathleen Bonnycastle, Lori L. Njølstad, Inger Wilsgaard, Tom Ganna, Andrea Rehnberg, Emil Hingorani, Aroon Kivimaki, Mika Kumari, Meena Assimes, Themistocles L. Barroso, Inês Boehnke, Michael Borecki, Ingrid B. Deloukas, Panos Fox, Caroline S. Frayling, Timothy Groop, Leif C. Haritunians, Talin Hunter, David Ingelsson, Erik Kaplan, Robert Mohlke, Karen L. O'Connell, Jeffrey R. Schlessinger, David Strachan, David P. Stefansson, Kari van Duijn, Cornelia M. Abecasis, Gonçalo R. McCarthy, Mark I. Hirschhorn, Joel N. Qi, Lu Loos, Ruth J. F. Lindgren, Cecilia M. North, Kari E. Heid, Iris M. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| title | Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| title_full | Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| title_fullStr | Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| title_full_unstemmed | Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| title_short | Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits |
| title_sort | sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674993/ https://www.ncbi.nlm.nih.gov/pubmed/23754948 http://dx.doi.org/10.1371/journal.pgen.1003500 |
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