Combinatorial Clustering of Residue Position Subsets Predicts Inhibitor Affinity across the Human Kinome

The protein kinases are a large family of enzymes that play fundamental roles in propagating signals within the cell. Because of the high degree of binding site similarity shared among protein kinases, designing drug compounds with high specificity among the kinases has proven difficult. However, co...

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Detalles Bibliográficos
Autores principales: Bryant, Drew H., Moll, Mark, Finn, Paul W., Kavraki, Lydia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675009/
https://www.ncbi.nlm.nih.gov/pubmed/23754939
http://dx.doi.org/10.1371/journal.pcbi.1003087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675009/
https://www.ncbi.nlm.nih.gov/pubmed/23754939
http://dx.doi.org/10.1371/journal.pcbi.1003087

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