Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I

Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions. Its mode of action was proposed to involve inhibition of increased GRP78 (glucose regulated protein 78)...

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Detalles Bibliográficos
Autores principales: Thomas, Simmy, Sharma, Natasha, Gonzalez, Reyna, Pao, Peng-Wen, Hofman, Florence M., Chen, Thomas C., Louie, Stan G., Pirrung, Michael C., Schönthal, Axel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675020/
https://www.ncbi.nlm.nih.gov/pubmed/23755268
http://dx.doi.org/10.1371/journal.pone.0065695

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