Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach

Proteolytic processing of Gag and Gag-Pol polyproteins by the viral protease (PR) is crucial for the production of infectious HIV-1, and inhibitors of the viral PR are an integral part of current antiretroviral therapy. The process has several layers of complexity (multiple cleavage sites and substr...

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Detalles Bibliográficos
Autores principales: Könnyű, Balázs, Sadiq, S. Kashif, Turányi, Tamás, Hírmondó, Rita, Müller, Barbara, Kräusslich, Hans-Georg, Coveney, Peter V., Müller, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675044/
https://www.ncbi.nlm.nih.gov/pubmed/23754941
http://dx.doi.org/10.1371/journal.pcbi.1003103

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