Cargando…

High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction

OBJECTIVES: Low levels of high-density lipoprotein (HDL) cholesterol are associated with an increased risk of acute myocardial infarction possibly through impaired endothelial atheroprotection and decreased nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA) mediates endothelial fu...

Descripción completa

Detalles Bibliográficos
Autores principales: Lorin, Julie, Guilland, Jean-Claude, Korandji, Claudia, Touzery, Claude, Bichat, Florence, Chagnon, Aline, Cottin, Yves, Rochette, Luc, Vergely, Catherine, Zeller, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675048/
https://www.ncbi.nlm.nih.gov/pubmed/23755144
http://dx.doi.org/10.1371/journal.pone.0064796
_version_ 1782272462996635648
author Lorin, Julie
Guilland, Jean-Claude
Korandji, Claudia
Touzery, Claude
Bichat, Florence
Chagnon, Aline
Cottin, Yves
Rochette, Luc
Vergely, Catherine
Zeller, Marianne
author_facet Lorin, Julie
Guilland, Jean-Claude
Korandji, Claudia
Touzery, Claude
Bichat, Florence
Chagnon, Aline
Cottin, Yves
Rochette, Luc
Vergely, Catherine
Zeller, Marianne
author_sort Lorin, Julie
collection PubMed
description OBJECTIVES: Low levels of high-density lipoprotein (HDL) cholesterol are associated with an increased risk of acute myocardial infarction possibly through impaired endothelial atheroprotection and decreased nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA) mediates endothelial function by inhibiting nitric oxide synthase activity. In patients with acute myocardial infarction, we investigated the relationship between serum levels of HDL and ADMA. APPROACH AND RESULTS: Blood samples from 612 consecutive patients hospitalized for acute MI <24 hours after symptom onset were taken on admission. Serum levels of ADMA, its stereoisomer, symmetric dimethylarginine (SDMA) and L-arginine were determined using high-performance liquid chromatography. Patients with low HDL (<40 mg/dL for men and <50 mg/dL for women) were compared with patients with higher HDL. Most patients (59%) had low HDL levels. Median ADMA levels were markedly higher in the low HDL group (0.69 vs. 0.50 µmole/L, p<0.001). In contrast, SDMA and L-arginine levels were similar for the two groups (p = 0.120 and p = 0.064). Notably, ADMA, but not SDMA or L-arginine, was inversely correlated with HDL (r = −0.311, p<0.001). In stratified analysis, this relationship was only found for low HDL levels (r = −0.265, p<0.001), but not when HDL levels were higher (r = −0.077, p = 0.225). By multivariate logistic regression analysis, ADMA level was strongly associated with low HDL levels (OR(95%CI):6.06(3.48–10.53), p<0.001), beyond traditional confounding factors. CONCLUSIONS: Our large population-based study showed for the first time a strong inverse relationship between HDL and ADMA in myocardial infarction patients, suggesting a functional interaction between HDL and endothelium, beyond metabolic conditions associated with low HDL levels.
format Online
Article
Text
id pubmed-3675048
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-36750482013-06-10 High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction Lorin, Julie Guilland, Jean-Claude Korandji, Claudia Touzery, Claude Bichat, Florence Chagnon, Aline Cottin, Yves Rochette, Luc Vergely, Catherine Zeller, Marianne PLoS One Research Article OBJECTIVES: Low levels of high-density lipoprotein (HDL) cholesterol are associated with an increased risk of acute myocardial infarction possibly through impaired endothelial atheroprotection and decreased nitric oxide (NO) bioavailability. Asymmetric dimethylarginine (ADMA) mediates endothelial function by inhibiting nitric oxide synthase activity. In patients with acute myocardial infarction, we investigated the relationship between serum levels of HDL and ADMA. APPROACH AND RESULTS: Blood samples from 612 consecutive patients hospitalized for acute MI <24 hours after symptom onset were taken on admission. Serum levels of ADMA, its stereoisomer, symmetric dimethylarginine (SDMA) and L-arginine were determined using high-performance liquid chromatography. Patients with low HDL (<40 mg/dL for men and <50 mg/dL for women) were compared with patients with higher HDL. Most patients (59%) had low HDL levels. Median ADMA levels were markedly higher in the low HDL group (0.69 vs. 0.50 µmole/L, p<0.001). In contrast, SDMA and L-arginine levels were similar for the two groups (p = 0.120 and p = 0.064). Notably, ADMA, but not SDMA or L-arginine, was inversely correlated with HDL (r = −0.311, p<0.001). In stratified analysis, this relationship was only found for low HDL levels (r = −0.265, p<0.001), but not when HDL levels were higher (r = −0.077, p = 0.225). By multivariate logistic regression analysis, ADMA level was strongly associated with low HDL levels (OR(95%CI):6.06(3.48–10.53), p<0.001), beyond traditional confounding factors. CONCLUSIONS: Our large population-based study showed for the first time a strong inverse relationship between HDL and ADMA in myocardial infarction patients, suggesting a functional interaction between HDL and endothelium, beyond metabolic conditions associated with low HDL levels. Public Library of Science 2013-06-06 /pmc/articles/PMC3675048/ /pubmed/23755144 http://dx.doi.org/10.1371/journal.pone.0064796 Text en © 2013 Lorin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lorin, Julie
Guilland, Jean-Claude
Korandji, Claudia
Touzery, Claude
Bichat, Florence
Chagnon, Aline
Cottin, Yves
Rochette, Luc
Vergely, Catherine
Zeller, Marianne
High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
title High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
title_full High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
title_fullStr High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
title_full_unstemmed High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
title_short High Levels of Asymmetric Dimethylarginine Are Strongly Associated with Low HDL in Patients with Acute Myocardial Infarction
title_sort high levels of asymmetric dimethylarginine are strongly associated with low hdl in patients with acute myocardial infarction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675048/
https://www.ncbi.nlm.nih.gov/pubmed/23755144
http://dx.doi.org/10.1371/journal.pone.0064796
work_keys_str_mv AT lorinjulie highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT guillandjeanclaude highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT korandjiclaudia highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT touzeryclaude highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT bichatflorence highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT chagnonaline highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT cottinyves highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT rochetteluc highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT vergelycatherine highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction
AT zellermarianne highlevelsofasymmetricdimethylargininearestronglyassociatedwithlowhdlinpatientswithacutemyocardialinfarction