Resistance to Oncolytic Myxoma Virus Therapy in Nf1(−/−)/Trp53(−/−) Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Despite promising preclinical studies, oncolytic viral therapy for malignant gliomas has resulted in variable, but underwhelming results in clinical evaluations. Of concern are the low levels of tumour infection and viral replication within the tumour. This discrepancy between the laboratory and the...

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Detalles Bibliográficos
Autores principales: Zemp, Franz J., McKenzie, Brienne A., Lun, Xueqing, Maxwell, Lori, Reilly, Karlyne M., McFadden, Grant, Yong, V. Wee, Forsyth, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675064/
https://www.ncbi.nlm.nih.gov/pubmed/23762429
http://dx.doi.org/10.1371/journal.pone.0065801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675064/
https://www.ncbi.nlm.nih.gov/pubmed/23762429
http://dx.doi.org/10.1371/journal.pone.0065801

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