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Resistance to Oncolytic Myxoma Virus Therapy in Nf1(−/−)/Trp53(−/−) Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon
Despite promising preclinical studies, oncolytic viral therapy for malignant gliomas has resulted in variable, but underwhelming results in clinical evaluations. Of concern are the low levels of tumour infection and viral replication within the tumour. This discrepancy between the laboratory and the...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675064/ https://www.ncbi.nlm.nih.gov/pubmed/23762429 http://dx.doi.org/10.1371/journal.pone.0065801 |