MiR-7 Triggers Cell Cycle Arrest at the G1/S Transition by Targeting Multiple Genes Including Skp2 and Psme3

MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and Psme3, to promote increased levels of p27(KIP) and temporary growth arrest of CHO...

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Detalles Bibliográficos
Autores principales: Sanchez, Noelia, Gallagher, Mark, Lao, Nga, Gallagher, Clair, Clarke, Colin, Doolan, Padraig, Aherne, Sinead, Blanco, Alfonso, Meleady, Paula, Clynes, Martin, Barron, Niall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675065/
https://www.ncbi.nlm.nih.gov/pubmed/23762407
http://dx.doi.org/10.1371/journal.pone.0065671

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