Cargando…

Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vγ9Vδ2 T Cell-Mediated Cytotoxicity

Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Todaro, Matilde, Orlando, Valentina, Cicero, Giuseppe, Caccamo, Nadia, Meraviglia, Serena, Stassi, Giorgio, Dieli, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675136/ https://www.ncbi.nlm.nih.gov/pubmed/23762301 http://dx.doi.org/10.1371/journal.pone.0065145

Ejemplares similares

Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells
por: Todaro, Matilde, et al.
Publicado: (2013)

Activation and selective IL-17 response of human Vγ9Vδ2 T lymphocytes by TLR-activated plasmacytoid dendritic cells
por: Presti, Elena Lo, et al.
Publicado: (2016)

Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes
por: Dieli, Francesco, et al.
Publicado: (2013)

Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas
por: Cordova, Adriana, et al.
Publicado: (2012)

IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
por: Caccamo, Nadia, et al.
Publicado: (2012)

Skewed Differentiation of Circulating Vγ9Vδ2 T Lymphocytes in Melanoma and Impact on Clinical Outcome
por: Toia, Francesca, et al.
Publicado: (2016)

Downregulation of miRNA17–92 cluster marks Vγ9Vδ2 T cells from patients with rheumatoid arthritis
por: Guggino, Giuliana, et al.
Publicado: (2018)

Colorectal Cancer Stem Cells and Cell Death
por: Catalano, Veronica, et al.
Publicado: (2011)

Colon Cancer Stem Cells: Bench-to-Bedside—New Therapeutical Approaches in Clinical Oncology for Disease Breakdown
por: Di Franco Simone, Simone, et al.
Publicado: (2011)

Differentiation of Effector/Memory Vδ2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites
por: Dieli, Francesco, et al.
Publicado: (2003)

ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis
por: Di Franco, Simone, et al.
Publicado: (2016)

B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells
por: Lu, Huimin, et al.
Publicado: (2020)

γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion
por: Lo Presti, Elena, et al.
Publicado: (2018)

Phenotype and functional changes of Vγ9/Vδ2 T lymphocytes in Behçet's disease and the effect of infliximab on Vγ9/Vδ2 T cell expansion, activation and cytotoxicity
por: Accardo-Palumbo, Antonina, et al.
Publicado: (2010)

γδ T cells and their clinical application in colon cancer
por: Corsale, Anna Maria, et al.
Publicado: (2023)

Control of CD56 expression and tumor cell cytotoxicity in human Vγ2Vδ2 T cells
por: Urban, Elizabeth M, et al.
Publicado: (2009)

Expansion With IL-15 Increases Cytotoxicity of Vγ9Vδ2 T Cells and Is Associated With Higher Levels of Cytotoxic Molecules and T-bet
por: Aehnlich, Pia, et al.
Publicado: (2020)

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence
por: Xu, Weili, et al.
Publicado: (2018)

Potentiating Vγ9Vδ2 T cell proliferation and assessing their cytotoxicity towards adherent cancer cells at the single cell level
por: Liu, Chenxiao, et al.
Publicado: (2022)

Lymphopenia in COVID-19: γδ T Cells-Based Therapeutic Opportunities
por: Lo Presti, Elena, et al.
Publicado: (2021)

Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells
por: Gu, Siyi, et al.
Publicado: (2015)

Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells
por: Okuno, Daisuke, et al.
Publicado: (2020)

Chitosan Nanoparticles Strengthen Vγ9Vδ2 T-Cell Cytotoxicity Through Upregulation Of Killing Molecules And Cytoskeleton Polarization
por: Lin, Li, et al.
Publicado: (2019)

Are human Vδ2(pos) T cells really resistant to aging and Human Cytomegalovirus infection?()
por: Mikulak, Joanna, et al.
Publicado: (2019)

Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis
por: La Manna, Marco P., et al.
Publicado: (2020)

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform
por: Di Rocco, Giuliana, et al.
Publicado: (2015)

Myeloid-Derived Suppressor Cells Specifically Suppress IFN-γ Production and Antitumor Cytotoxic Activity of Vδ2 T Cells
por: Sacchi, Alessandra, et al.
Publicado: (2018)

Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer
por: Hoeres, Timm, et al.
Publicado: (2018)

Development and Selection of the Human Vγ9Vδ2(+) T-Cell Repertoire
por: Willcox, Carrie R., et al.
Publicado: (2018)

The PPARα pathway in Vγ9Vδ2 T cell anergy
por: Poupot, Mary, et al.
Publicado: (2014)

Releasing the restraints of Vγ9Vδ2 T-cells in cancer immunotherapy
por: Ridgley, Laura A., et al.
Publicado: (2023)

New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
por: Kamizela, Angelika, et al.
Publicado: (2019)

Meeting the Challenge of Targeting Cancer Stem Cells
por: Turdo, Alice, et al.
Publicado: (2019)

Role of Type I and II Interferons in Colorectal Cancer and Melanoma
por: Di Franco, Simone, et al.
Publicado: (2017)

Preferential Infiltration of Unique Vγ9Jγ2-Vδ2 T Cells Into Glioblastoma Multiforme
por: Lee, Mijeong, et al.
Publicado: (2019)

Estrogens and Stem Cells in Thyroid Cancer
por: Zane, Mariangela, et al.
Publicado: (2014)

Role of Vγ9Vδ2+ γδ T cells in juvenile idiopathic arthritis
por: Gerstein, M, et al.
Publicado: (2008)

BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation
por: Gertner-Dardenne, Julie, et al.
Publicado: (2013)

An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells
por: Herrmann, Thomas, et al.
Publicado: (2020)

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2(pos) T cells in elderly patients affected by liver metastatic colorectal cancer
por: Bruni, Elena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7e3bk50t0djv8en4j2o6153qjn